Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis

Billings, Caroline; Anderson, David E.

doi:10.3390/bioengineering9020065

Cited by 7 publications

(5 citation statements)

References 202 publications

(491 reference statements)

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“…Biocompatibility, degradability, and sustained drug release are the fundamental characteristics of successful biomaterials targeting bone infection. 78 As a clinically used carrier, PMMA loaded with vancomycin shows bacterial load reduction but cannot eradicate the biofilm. 27 , 34 However, the primary concern is the elution from the depot to the surrounding tissue, which may fail to reach the optimal concentration.…”

Section: Discussionmentioning

confidence: 99%

Current therapeutic interventions combating biofilm-related infections in orthopaedics

Cheung

Chow

et al. 2022

Bone & Joint Research

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Aims Biofilm-related infection is a major complication that occurs in orthopaedic surgery. Various treatments are available but efficacy to eradicate infections varies significantly. A systematic review was performed to evaluate therapeutic interventions combating biofilm-related infections on in vivo animal models. Methods Literature research was performed on PubMed and Embase databases. Keywords used for search criteria were “bone AND biofilm”. Information on the species of the animal model, bacterial strain, evaluation of biofilm and bone infection, complications, key findings on observations, prevention, and treatment of biofilm were extracted. Results A total of 43 studies were included. Animal models used included fracture-related infections (ten studies), periprosthetic joint infections (five studies), spinal infections (three studies), other implant-associated infections, and osteomyelitis. The most common bacteria were Staphylococcus species. Biofilm was most often observed with scanning electron microscopy. The natural history of biofilm revealed that the process of bacteria attachment, proliferation, maturation, and dispersal would take 14 days. For systemic mono-antibiotic therapy, only two of six studies using vancomycin reported significant biofilm reduction, and none reported eradication. Ten studies showed that combined systemic and topical antibiotics are needed to achieve higher biofilm reduction or eradication, and the effect is decreased with delayed treatment. Overall, 13 studies showed promising therapeutic potential with surface coating and antibiotic loading techniques. Conclusion Combined topical and systemic application of antimicrobial agents effectively reduces biofilm at early stages. Future studies with sustained release of antimicrobial and biofilm-dispersing agents tailored to specific pathogens are warranted to achieve biofilm eradication. Cite this article: Bone Joint Res 2022;11(10):670–684.

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Section: Discussionmentioning

confidence: 99%

Current therapeutic interventions combating biofilm-related infections in orthopaedics

Cheung

Chow

et al. 2022

Bone & Joint Research

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“…Coating of implantable devices-Coating of implantable devices like heart valves prevents adhesion and further growth of bacteria like E. coli, reducing the risk of inflammation and infections [80,81]. Devices that are commonly prone to the colonization of bacteria, such as dental implants, catheters, etc., are generally subjected to NP coatings [56,62].…”

Section: Bio-medical Antimicrobial Applications Of Metal-based Npsmentioning

confidence: 99%

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Kaur

Kaur²,

Alyami

et al. 2023

Antibiotics

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The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.

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“…Poly(methyl methacrylate) (PMMA) beads, calcium sulfate and calcium phosphate are the most common bone cement materials used for antibiotic delivery. While an extensive discussion of these materials is beyond the scope of this review, several good reviews have been published recently, including reviews by Masters et al in 2019 [48], Kyriacou et al in 2020 [49], Cyphert et al in 2021 [50], and Billings and Anderson in 2022 [51]. Within these materials, several antibiotics including gentamicin [52,53], ceftriaxone [54], tobramycin [55], and vancomycin [56] have been successfully loaded and clinically tested.…”

Section: Nanotechnology In Osteomyelitis Treatmentmentioning

confidence: 99%

Nanotechnology in the Diagnosis and Treatment of Osteomyelitis

et al. 2022

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Infection remains one of the largest threats to global health. Among those infections that are especially troublesome, osteomyelitis, or inflammation of the bone, typically due to infection, is a particularly difficult condition to diagnose and treat. This difficulty stems not only from the biological complexities of opportunistic infections designed to avoid the onslaught of both the host immune system as well as exogenous antibiotics, but also from changes in the host vasculature and the heterogeneity of infectious presentations. While several groups have attempted to classify and stage osteomyelitis, controversy remains, often delaying diagnosis and treatment. Despite a host of preclinical treatment advances being incubated in academic and company research and development labs worldwide, clinical treatment strategies remain relatively stagnant, including surgical debridement and lengthy courses of intravenous antibiotics, both of which may compromise the overall health of the bone and the patient. This manuscript reviews the current methods for diagnosing and treating osteomyelitis and then contemplates the role that nanotechnology might play in the advancement of osteomyelitis treatment.

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Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis

Cited by 7 publications

References 202 publications

Current therapeutic interventions combating biofilm-related infections in orthopaedics

Current therapeutic interventions combating biofilm-related infections in orthopaedics

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Nanotechnology in the Diagnosis and Treatment of Osteomyelitis

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