Synthesis and Characterisation of Silicon-Substituted Hydroxyapatite

Marques, Paulo; Magalhães, M. Clara F.; Correia, Raquel; Vallet‐Regí, María

doi:10.4028/www.scientific.net/kem.192-195.247

Cited by 28 publications

(18 citation statements)

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“…The substituted amount of Si in synthesized hydroxyapatite using our method is higher than the values reported in the literature [17][18][19][20][21]. This is attributed to the fact that our synthetic procedure incorporated silicon from soluble silicate species which is closer to calcification under physiological conditions than any previous silicate-substituted hydroxyapatite preparation.…”

Section: Discussioncontrasting

confidence: 80%

“…In addition, several studies have proposed the remarkable importance of silicon on bone formation and growth [13][14][15][16][17] at in vitro and in vivo conditions. Generally, silicon-substituted HAP was prepared from two silicon sources; silicon acetate [17][18][19] and tetraethyl orthosilicate (TEOS) [20][21][22]. We have recently developed multi-substituted HAP powders by wet chemical precipitation route at 37 • C in presence of different concentrations of sodium silicate and open to atmosphere to allow for CO 3 2− incorporation [23].…”

Section: Introductionmentioning

confidence: 99%

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Sintering behavior and thermal stability of Na+, SiO44− and CO32− co-substituted hydroxyapatites

Mostafa

Hassan

Mohamed

2009

Journal of Alloys and Compounds

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Sintering behavior and thermal stability of Na+, SiO44− and CO32− co-substituted hydroxyapatites

Mostafa

Hassan

Mohamed

2009

Journal of Alloys and Compounds

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“…However, although Si 4+ ionic radius is bigger than that of P 5+ , the P = O and P-O bonds (0.155 nm) are shorter than the Si-O bonds (0.161 nm), and hence the radius of the -PO 4 tetrahedra is effectively smaller than that of the SiO 4 tetrahedra [471]. In fact, some authors reported a small decrement of the reticular parameter a and an increase of the c value for Si content of 0.4-1.5 wt% [71,427,434,436,438,471].…”

Section: àmentioning

confidence: 95%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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“…These authors studied the effects of low substitution levels on the biocompatibility and in vitro bioactivity, determining the ability to form the apatite-like layer by soaking the materials in a simulated body fluid (SBF). 18 Also, Marques et al 19 synthesized using also a wet method, hydroxyapatite with silicon content up to 0.15 wt %, having stable materials at 1300°C and noting that the volume of unit cell and the a parameter length of the hydroxyapatite decreased as the silicon content increased.…”

Section: Introductionmentioning

confidence: 99%

In vitro bioactivity of silicon‐substituted hydroxyapatites

Balas¹,

Pérez‐Pariente²,

Vallet‐Regí³

2003

J Biomedical Materials Res

182

119

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Silicon-containing hydroxyapatites were synthesized by the controlled crystallization method. Chemical analysis, N(2) adsorption, Hg porosimetry, X-ray diffraction, scanning electron microscopy-energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy (XPS) were used to characterize the hydroxyapatite and to monitor the development of a calcium phosphate layer onto the surface of the substrate immersed in a simulated body fluid, that is, in vitro bioactivity tests. The influence of the silicon content and the nature of the starting calcium and phosphorus sources on the in vitro bioactivity of the resulting materials were studied. A sample of silicocarnotite, whose structure is related to that of hydroxyapatite and contains isolated SiO(4) (4-) anions that isomorphically substitute some PO(4) (3-) anions, was prepared and used as reference material for XPS studies. An increase of the unit cell parameters with the Si content was observed, which indicated that SiO(4) (4-) units are present in lattice positions, replacing some PO(4) (3-) groups. By using XPS it was possible to assess the presence of monomeric SiO(4) (4-) units in the surface of apatite samples containing 0.8 wt % of silicon, regardless the nature of the starting raw materials, either Ca(NO(3))(2)/(NH(4))(2)HPO(4)/Si(OCOCH(3))(4) or Ca(OH)(2)/H(3)PO(4)/Si(OCOCH(3))(4). However, an increase of the silicon content up to 1.6 wt % leads to the polymerization of the silicate species at the surface. This technique shows silicon enrichment at the surface of the three samples. The in vitro bioactivity assays showed that the formation of an apatite-like layer onto the surface of silicon-containing substrates is strongly enhanced as compared with pure silicon-free hydroxyapatite. The samples containing monomeric silicate species showed higher in vitro bioactivity than that of silicon-rich sample containing polymeric silicate species. The use of calcium and phosphate salts as precursors lead to materials with higher bioactivity.

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Synthesis and Characterisation of Silicon-Substituted Hydroxyapatite

Cited by 28 publications

References 0 publications

Sintering behavior and thermal stability of Na+, SiO44− and CO32− co-substituted hydroxyapatites

Sintering behavior and thermal stability of Na+, SiO44− and CO32− co-substituted hydroxyapatites

Cationic and Anionic Substitutions in Hydroxyapatite

In vitro bioactivity of silicon‐substituted hydroxyapatites

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