Synthesis and Characterisation of Nano-Engineered Polycaprolactone-Nano Hydroxyapatite Scaffold for Bone Defect Application

Harikrishnan, P.; Raheja, Anant; Sivasamy, A.

doi:10.1166/mat.2018.1542

Cited by 3 publications

(2 citation statements)

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“…At present, several scholars have used PCL as a matrix for research on bone scaffolds. However, their manufacturing processes are mostly focused on electrospun nanofibers and fused deposition modeling (FDM) [29][30][31]. Yedekci et al [32] used PCL as the main raw material for bone tissue engineering, demonstrating its excellent biological performance.…”

Section: Dlp 3d Printing 321 Dlp 3d Printing Of Femoral Modelmentioning

confidence: 99%

Digital light 3D printing of artificial bone with star-shaped polycaprolactone-based polyurethane acrylate

Yang,

Qiu,

et al. 2024

Mater. Res. Express

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Advanced medical materials and manufacturing technologies are highly in demand in artificial bones. Herein, a four-arm star-shaped polycaprolactone polyurethane acrylate (FPCLA) was designed and synthesized. The photosensitive character of FPCLA contributed to the rapid prototyping and personalized customization under digital light processing (DLP) 3D printing technology. The FPCLA was prepared by introducing unsaturated double bonds into polycaprolactone tetraethyl alcohol (PCLT). We characterized the physico-chemical properties of the material through FTIR, H-NMR, GPC, DSC and SEM. Cell behaviors on material were observed in vitro. In addition, we employed a DLP 3D printer to evaluate the feasibility of FPCLA to fabricate artificial bone model. The photocuring star polycaprolactone was confirmed in detail by detection method. SEM analyses demonstrated that FPCLA has good tenacity. The material can be used to fabricated artificial bone with a diameter of 3.02 mm at its narrowest by DLP 3D printing technology. The cell survival rates of CCK-8 and Live/Dead fluorescence staining experiments were both above 90%, which indicated safety and feasibility of such new-generation artificial bone made of synthetic polymers.

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Section: Dlp 3d Printing 321 Dlp 3d Printing Of Femoral Modelmentioning

confidence: 99%

Digital light 3D printing of artificial bone with star-shaped polycaprolactone-based polyurethane acrylate

Yang,

Qiu,

et al. 2024

Mater. Res. Express

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“…Hydroxyapatite-based biomaterials can serve as both a bone substitute and an osteoconductive scaffold, owing to their exceptional biocompatibility and close resemblance in chemical composition to the mineral phase found in bone. Incorporating hydroxyapatite on their surfaces enhances the stability and biocompatibility of copper oxide nanoparticles [3]. Research findings indicate that the incorporation of copper into the structure of HAp enhances its bioactivity [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Comparison of Chemical Changes Using FTIR Spectroscop for Copper Substituted Hydroxyapatite

Mounika,

Ramakrishnan

2024

E3S Web Conf.

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The study aims to scrutinise and compare the chemical modifications present in copper-substituted hydroxyapatite utilising FT-IR spectroscopy. The synthesis of both HAp and Cu-modified HAp was conducted via the chemical precipitation method, involving specific chemicals like ammonium hydroxide (HN4OH) solution, diammonium hydrogen phosphate ((NH4)2HPO4), copper chloride hexahydrate (CuCl2.6H2O), and calcium nitrate tetrahydrate (Ca(NO3)2.4H2O). The overall sample size was determined through clinlac.com considering the copper-substituted dataset (N=4), an alpha error of 0.05, G power at 80%, an enrolment ratio of 0.1, and a confidence interval of 95%. The acquired FT-IR spectra denote minimal differences between the CuHAp and HAp samples. Each peak bears a resemblance to the distinctive features of HAp, indicating structural similarity between pure hydroxyapatite and the copper-substituted variant. The investigation utilised SPSS 27.0.1 software to compute the copper-doped hydroxyapatite percentages at 0%, 1%, 5%, and 10%. A One Sample T-test revealed a statistically significant difference with a p-value of 0.001 (p<0.05), particularly highlighting the statistical significance of copper hydroxyapatite weight percentage (p=0.006). Significant alterations in peak values were observed in the novel copper-substituted hydroxyapatite concentrations of 1%, 5%, and 10%. Notably, the study identifies the 10% copper and hydroxyapatite combination as yielding the most noteworthy chemical modifications via spectroscopy. This finding suggests the potential utility of these compounds in medicinal applications.

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Recently Emerging Trends in Bone Replacement Polymer Nanocomposites

Idumah

Mohamad

Hassan

et al. 2019

Nanostructured Polymer Composites for Biomedical Applications

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Synthesis and Characterisation of Nano-Engineered Polycaprolactone-Nano Hydroxyapatite Scaffold for Bone Defect Application

Cited by 3 publications

References 0 publications

Digital light 3D printing of artificial bone with star-shaped polycaprolactone-based polyurethane acrylate

Digital light 3D printing of artificial bone with star-shaped polycaprolactone-based polyurethane acrylate

Synthesis and Comparison of Chemical Changes Using FTIR Spectroscop for Copper Substituted Hydroxyapatite

Recently Emerging Trends in Bone Replacement Polymer Nanocomposites

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