Synthesis and Characterisation of Gelatin-PVA/Hydroxyapetite(HAP) Composite for Medical Applications

Basak, Piyali; Pahari, Purbanka; Das, Pratik; Das, Nirmalya Sankar; Samanta, Sujan Krishna; Roy, Sukumar

doi:10.1088/1757-899x/410/1/012021

Cited by 9 publications

(23 citation statements)

References 10 publications

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“…The appearance of a peak at 965 cm −1 , related to the asymmetric stretching mode of P-O of the PO 4 3− group, and change of the intensity of peaks at 3360, 1710, 1640, and 1240 cm −1 confirmed the presence of Hap incorporated in scaffolds [ 54 , 55 ]. Apatite crystalized as a single phase with hexagonal structure (PDF 01-089-6438) and its FTIR spectrum contains all characteristic bands, including vibrations of PO 4 3− groups at 472, 583, 601, 961, 1032, and 1108 cm −1 and OH - vibrations at 3573 and 632 cm −1 (an insert in Figure 1 ) [ 56 ].…”

Section: Resultsmentioning

confidence: 97%

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

et al. 2021

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Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material’s composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.

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Section: Resultsmentioning

confidence: 97%

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

et al. 2021

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“…In contrast, Al-Mamun et al [52] used a higher concentration of 0.11 g/mL. Another study performed by Basak et al [53] described 5% of gelatin, however, Jain et al [54] used three different percentages of gelatin that are 1%, 2% and 3%. The PVA concentration in Al-Mamun et al [52] and Ismaiel [51] was 0.11 and 0.032 g/mL, respectively for their blended gelatin-PVA.…”

Section: Fabrication Of Gelatin-pva Filmmentioning

confidence: 99%

“…Furthermore, Chaibi [50] scrutinised that PVA has been used around 0.2% by weight/volume. Basak [53] and Jain [54] research reported that they used 5% and 10% PVA, respectively. The blended approach needs the best ratio of gelatin and PVA to fabricate a suitable film for different applications.…”

Section: Fabrication Of Gelatin-pva Filmmentioning

confidence: 99%

“…Al-Mamun et al [52] and Ebnalwaled et al [55] reported a 1:1 ratio of gelatin to PVA. In contrast, Basak et al [53] and Chaibi et al [50] used fixed ratios, which are 1:2 and 29:43, respectively. The remaining studies from other articles had various ratios per study for their optimisation purposes.…”

Section: Fabrication Of Gelatin-pva Filmmentioning

confidence: 99%

“…Basak et al [53] and Chaibi et al [50] used glutaraldehyde as a crosslinker while Al-Mamun et al [52], Ismaiel et al [51], Ebnalwaled et al [55] and Khan et al [56] reported the use of gamma-irradiation as a method of crosslinking. While there are some studies that did not use any crosslinkers in their fabrication methods.…”

Section: Fabrication Of Gelatin-pva Filmmentioning

confidence: 99%

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Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review

Zulkiflee

2021

Biomedicines

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The field of biomaterials has been steadily expanding as a large number of pharmaceutical and manufacturing companies invest in research in order to commercialize biomaterial products. Various three-dimensional biomaterials have been explored including film, hydrogel, sponge, microspheres etc., depending on different applications. Thus, gelatin and polyvinyl alcohol (PVA) are widely used as a natural- and synthetic-based biomaterial, respectively, for tissue engineering and clinical settings. The combination of these materials has proven its synergistic effects in wound-healing applications. Therefore, this review aims to highlight the hybrid gelatin and PVA thin film development and evaluate its potential characteristics for tissue engineering applications from existing published evidence (within year 2010–2020). The primary key factor for polymers mixing technology might improve the quality and the efficacy of the intended polymers. This review provides a concise overview of the current knowledge for hybrid gelatin and PVA with the method of fabricating and mixing technology into thin films. Additionally, the findings guided to an optimal fabrication method and scrutinised characterisation parameters of fabricated gelatin-PVA thin film. In conclusion, hybrid gelatin-PVA thin film has higher potential as a treatment for various biomedical and clinical applications.

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PVA/CMC/Attapulgite Clay Composite Hydrogel Membranes for Biomedical Applications: Factors Affecting Hydrogel Membranes Crosslinking and Bio-evaluation Tests

et al. 2022

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Herein, polyvinyl alcohol-carboxymethyl cellulose (PVA-CMC) composite hydrogel membranes were prepared using solution-casting method, where citric acid (CA) was added as crosslinker in different ratios of (7, 10 and12 wt%). Attapulgite clay extracted from Northwestern Desert of Borg El-Arab, Egypt; was incorporated as nanofiller (1, 2, 4, and 5 wt%) into membranes for improving their mechanical/ thermal stability. Results revealed that, physicochemical properties of membranes e.g. swelling%, tensile strength and morphology of membranes affected significantly by different clay concentrations and citric acid crosslinker. Also, attapulgite clay with concentration 1 (wt%) enhanced mechanical strength of composite membranes, compared to other clay concentrations. Furthermore, protein adsorption %, hydrolytic degradation, hemolysis (%) and antimicrobial activity significantly affected by clay contents and CA concentrations. Four bacterial pathogens e.g. Candida albicans, Escherichia coli, Klebsiella pneumoniae, and Bacillus cereus were used for testing antimicrobial activity of prepared membranes. Results referred to increasing of clay contents led to a high hemolysis %; however, increasing CA concentration significantly reduced hemolysis %. Meanwhile, membranes with low clay contents offered the most effective resistance against tested microbes. These findings are referring to the ability of using PVA-CMC-attapulgite composite membranes crosslinked by CA as good candidate of biomaterials for dermal wound dressings.

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Synthesis and Characterisation of Gelatin-PVA/Hydroxyapetite(HAP) Composite for Medical Applications

Cited by 9 publications

References 10 publications

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review

PVA/CMC/Attapulgite Clay Composite Hydrogel Membranes for Biomedical Applications: Factors Affecting Hydrogel Membranes Crosslinking and Bio-evaluation Tests

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