Synthesis and blood compatibilities of novel segmented polyurethanes grafted phospholipid analogous vinyl monomers and polyfunctional monomers

Abstract

New segmented polyurethanes (SPUs) grafted phospholipid analogous vinyl monomers and polyfunctional monomers were synthesized. The soft segments used in this study were poly(butadiene). The hard segments of these polyurethanes were 4,49-methylenediphenyl diisocyanate and 1,4-butanediol. The blood compatibilities of the new polymers were evaluated by platelet rich plasma (PRP) contact studies and viewed by scanning electron microscopy (SEM) using medical grade BioSpan and non-phospholipid polyurethane as a reference. The clotting times of the materials in contact with platelet poor plasma (PPP) were also measured. These results of two evaluations suggest that these grafted polymers may be regarded as hopeful biomaterials.

Construction of a Biomimetic Surface on Microfluidic Chips for Biofouling Resistance

“…As nature biomolecules, phospholipids are found in various cellular membranes. Recently, much attention has been devoted to the polymeric phospholipid analogues containing phosphatidylcholine moieties that exist on the surface of the phospholipid bilayer. , Using phospholipids to modify the polymer surfaces has attracted considerable interest as a means of improving their biocompatibility and inhibiting protein adsorption or cell adhesion. A series of phospholipid polymers shows excellent biological properties at the interface to develop various new biomaterials useful in biotechnology .…”

Natural-Based Polyurethane Biomaterials for Medical Applications

“…In our previous paper, the fibrinogen adsorption tests, (Macocinschi et al, 2009a), revealed that PTHF-HPC and PEA-HPC polyurethanes proved to be indicated for thromboresistant devices, and the polyether-urethane PTHF-HPC proved to have more relevant haemocompatible material qualities. From literature for Biospan polyurethane, (Korematsu et al, 1999), the values for adhered thrombocytes found are 101500 adhered thrombocytes per mm 2 . The number of adhered platelet is sensitive also to the soft segment length in the case of fluorinated polyurethanes, (Wang & Wei, 2005).…”

Optimizing Fouling Resistance of Poly(Sulfabetaine)s through Backbone and Charge Separation

“…[7,[12][13][14][15] Several studies have shown that the precise molecular structure of these polymers affects their inertness against fouling. Essential molecular parameters include not only the chemistry of both the anionic and the cationic groups, [16][17][18][19][20][21][22][23][24][25] but also the nature of the polymer backbone, [16,17,22,[26][27][28][29] the distance of the zwitterionic moieties from the backbone, [16,[30][31][32] the zwitterion's dipole orientation, [18,[33][34][35][36] and the length of the alkylene spacer between the ionic groups. [17,[37][38][39] For instance, in a set of otherwise identical polycarboxybetaines with varying inter-charge spacer, the adsorption of blood protein fibrinogen was lowest for two carbon atoms separating the ammonium and the carboxylate groups, increasing in the order 2 < 1 < 3 < 5.…”