Natural-Based Polyurethane Biomaterials for Medical Applications

Macocinschi, Doina; Filip, Daniela; Vlad, Stelian

doi:10.5772/24219

Cited by 6 publications

(8 citation statements)

References 53 publications

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“…Any material designed to replace tissues for medical applications needs to have mechanical properties that can match the matrix of the host tissues without inducing any inflammation or toxicity. Also it needs to be easily processed and sterilized with an adequate shelf life (Macocinschi et al, ). PUs are elastomers with good biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

“…They belong to a family of materials with a diversity of chemical compositions, mechanical properties, tissue‐specific biocompatibility, and biodegradability (Zdrahala & Zdrahala, ). Their segmented block copolymer character endows them with a wide range of versatility in terms of tailoring their physical properties, blood, and tissue compatibility making them attractive for both hard and soft tissue engineering (Alperin, Zandstra, & Woodhouse, ; Macocinschi, Filip, & Vlad, ). Their ability to distend and recoil without wear makes them attractive for pediatric applications like cleft palate repair and alveolar ridge augmentation, where materials with high tensile strength are required.…”

Section: Introductionmentioning

confidence: 99%

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Developing a synthetic composite membrane for cleft palate repair

Sharif

Román

Asif

et al. 2019

J Tissue Eng Regen Med

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An oronasal fistula is a passage between the oral and nasal cavity. Currently, surgical procedures use mucosal flaps or collagen grafts to make a barrier between oral and nasal cavities. Our aim was to develop a cell-free synthetic repair material for closure of nasal fistulas. We surface functionalized electrospun polyurethane (PU) and poly-Llactic acid (PLLA) and composite polymer (PU-PLLA) membranes with acrylic acid through plasma polymerization. Membranes were treated in a layer-by-layer approach to develop highly charged electrostatic layer that could bind heparin as a pro-angiogenic glycosaminoglycan. The properties were evaluated through physical, chemical, and mechanical characterization techniques. Cytotoxicity was tested with MC3T3 pre-osteoblast cell lines for 3, 7, and 14 days, and vasculogenesis was assessed by implantation into the chorio-allantoic membrane in chick embryos for 7 days. In vivo biocompatibility was assessed by subcutaneous implantation in rats for 1, 3, and 6 weeks. The membranes consisted of random fibers of PLLA-PU with fiber diameters of 0.47 and 0.12 μm, respectively. Significantly higher cell proliferation and migration of MC3T3 cells at 3, 7, and 14 days were shown on plasmacoated membranes compared with uncoated membranes. Further, it was found that plasma-coated membranes were more angiogenic than controls. In vivo implantation of membranes in rats did not reveal any gross toxicity to the materials, and wound healing was comparable with the native tissue repair (sham group). We therefore present a plasma-functionalized electrospun composite polymer membrane for use in the treatment of fistulas. These membranes are flexible, non-cytotoxic, and angiogenic, and we hope it should lead to permanent closure of oronasal fistula.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Developing a synthetic composite membrane for cleft palate repair

Sharif

Román

Asif

et al. 2019

J Tissue Eng Regen Med

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“…Polymers are organic materials, macromolecules that result from smaller structural units (monomers) and are often used to replace soft tissue. Indeed, polymers are commonly used in the production of cardiovascular devices, including intravascular catheters the subject of this work [22].…”

Section: Biomaterialsmentioning

confidence: 99%

“…Some of the artificial polymers most used in biomedical applications are polytetrafluroethylene, polypropylene, polyamides, polyvinylchloride and poly(etherurethane) (i.e. a type of PU) [22].…”

Section: Polymers For Intravascular Cathetersmentioning

confidence: 99%

Prevention of intravascular catheter-related infections

2021

Indian J Cont Nsg Edn

575

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“…It exhibits good mechanical strength, good biocompatibility and easy processing, so it has been widely used in biomedical materials and can be used as a suitable small-diameter tissue engineering vascular scaffold material. 11,12 Currently, the ideal mechanical properties and hydrophilicity in the preparation of artificial vascular scaffolds are essential factors. The scaffold material with good mechanical strength can be sufficient to resist the impact of blood flow and ensure that it does not bend or break.…”

Section: Introductionmentioning

confidence: 99%

<p>Preparation of PU/Fibrin Vascular Scaffold with Good Biomechanical Properties and Evaluation of Its Performance in vitro and in vivo</p>

Lei

et al. 2020

IJN

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The development of tissue-engineered blood vessels provides a new source of donors for coronary artery bypass grafting and peripheral blood vessel transplantation. Fibrin fiber has good biocompatibility and is an ideal tissue engineering vascular scaffold, but its mechanical property needs improvement. Methods: We mixed polyurethane (PU) and fibrin to prepare the PU/fibrin vascular scaffolds by using electrospinning technology in order to enhance the mechanical properties of fibrin scaffold. We investigated the morphological, mechanical strength, hydrophilicity, degradation, blood and cell compatibility of PU/fibrin (0:100), PU/fibrin (5:95), PU/fibrin (15:85) and PU/fibrin (25:75) vascular scaffolds. Based on the results in vitro, PU/fibrin (15:85) was selected for transplantation in vivo to repair vascular defects, and the extracellular matrix formation, vascular remodeling, and immune response were evaluated. Results: The results indicated that the fiber diameter of the PU/fibrin (15:85) scaffold was about 712nm. With the increase of PU content, the mechanical strength of the composite scaffolds increased, however, the degradation rate decreased gradually. The PU/fibrin scaffold showed good hydrophilicity and hemocompatibility. PU/fibrin (15:85) vascular scaffold could promote the adhesion and proliferation of mesenchymal stromal cells (MSCs). Quantitative RT-PCR experimental results showed that the expression of collagen, survivin and vimentin genes in PU/fibrin (15:85) was higher than that in PU/fibrin (25:75). The results in vivo indicated the mechanical properties and compliance of PU/fibrin grafts could meet clinical requirements and the proportion of thrombosis or occlusion was significantly lower. The graft showed strong vasomotor response, and the smooth muscle cells, endothelial cells, and ECM deposition of the neoartery were comparable to that of native artery after 3 months. At 3 months, the amount of macrophages in PU/fibrin grafts was significantly lower, and the secretion of pro-inflammatory and anti-inflammatory cytokines decreased. Conclusion: PU/fibrin (15:85) vascular scaffolds had great potential to be used as smalldiameter tissue engineering blood vessels.

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Natural-Based Polyurethane Biomaterials for Medical Applications

Cited by 6 publications

References 53 publications

Developing a synthetic composite membrane for cleft palate repair

Developing a synthetic composite membrane for cleft palate repair

Prevention of intravascular catheter-related infections

<p>Preparation of PU/Fibrin Vascular Scaffold with Good Biomechanical Properties and Evaluation of Its Performance in vitro and in vivo</p>

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