Synthesis and Biomedical Applications of Multifunctional Nanoparticles

Kim, Dokyoon; Shin, Kwang‐Soo; Kwon, Soon Gu; Hyeon, Taeghwan

doi:10.1002/adma.201802309

Cited by 234 publications

(166 citation statements)

References 290 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…[3,4] Unfortunately, general oral medication is limited to the treatment of early stage atherosclerosis. [8][9][10][11] However, one shortcoming of conventional drug delivery nanosystems is the lack of site targeting. [5,6] Although surgical interventions (e.g., stenting) are effective for the treatment of advanced atherosclerosis, such procedures are associated with side effects such as restenosis and late stent thrombosis, which hampers the long-term success of surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

et al. 2019

View full text Add to dashboard Cite

Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one of the most common forms of the disease, is characterized by a gradual formation of atherosclerotic plaque, hardening, and narrowing of the arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy is substantially limited in vivo due to nonspecific clearance by the mononuclear phagocytic system. In order to address this limitation, rapamycin (RAP)‐loaded poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles are cloaked with the cell membrane of red blood cells (RBCs), creating superior nanocomplexes with a highly complex functionalized bio‐interface. The resulting biomimetic nanocomplexes exhibit a well‐defined “core–shell” structure with favorable hydrodynamic size and negative surface charge. More importantly, the biomimetic nature of the RBC interface results in less macrophage‐mediated phagocytosis in the blood and enhanced accumulation of nanoparticles in the established atherosclerotic plaques, thereby achieving targeted drug release. The biomimetic nanocomplexes significantly attenuate the progression of atherosclerosis. Additionally, the biomimetic nanotherapy approach also displays favorable safety properties. Overall, this study demonstrates the therapeutic advantages of biomimetic nanotherapy for atherosclerosis treatment, which holds considerable promise as a new generation of drug delivery system for safe and efficient management of atherosclerosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Up‐to‐date, functional nanosystems have been formulated from a plethora of inorganic and organic materials including synthetic block‐copolymers, natural origin biopolymers, and peptides/proteins that endow them with unique bioactivity, biocompatibility, biodegradability, and chemical versatility . This chemical flexibility and their high surface‐to‐volume ratio has been widely acknowledged and explored via precise chemical functionalization to imprint multifunctional features including cell/tissue targeting, adhesivity, and response to different stimuli . So far, numerous types of nanoparticles have been fabricated to precisely adapt or respond to magnetic fields, temperature, ultrasound, pH/redox/hypoxic microenvironments, enzymes, light, among others .…”

Section: Cell–biomaterials Assembliesmentioning

confidence: 99%

Advanced Bottom‐Up Engineering of Living Architectures

et al. 2019

View full text Add to dashboard Cite

Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom‐up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular‐rich structures or multicomponent cell–biomaterial synergies are described. An up‐to‐date critical overview of long‐term existing and rapidly emerging technologies for integrative bottom‐up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.

show abstract

“…Biogenic nanoparticles, or nanomaterials coated with natural compounds of plants and animal origin has produced tremendous antibacterial effects which could be of potential future value. Moreover, newer classes of antibiotics, which have not yet been tested against bacteria in conjugation with nanomaterials could also result in increased efficacy and slow down the chances of development of resistance [82]. Premature drug delivery and use of nanostructured carriers functionalized with antigen-specific ligands exhibited improvement in the treatment of infectious diseases and in systemic delivery [78].…”

Section: Potential Future Strategies Against Bacterial Infectionsmentioning

confidence: 99%

“…Recently, theranostics have gained significant importance in biomedical application and hold the promise of enabling pre-screening and therapeutics that may also be beneficial for antibacterial management [13]. However, the development of a practical and commercial application of nanotheranostic has not been yielded yet [82]. We anticipate that developing multiple functional modalities such as identification, isolation, and therapy at one platform will decrease the disease burden and will cause an overall improvement in the healthcare setting against bacterial infections.…”

Section: Potential Future Strategies Against Bacterial Infectionsmentioning

confidence: 99%

The Use of Nanomedicine for Targeted Therapy against Bacterial Infections

et al. 2019

View full text Add to dashboard Cite

The emergence of drug resistance combined with limited success in the discovery of newer and effective antimicrobial chemotherapeutics poses a significant challenge to human and animal health. Nanoparticles may be an approach for effective drug development and delivery against infections caused by multi-drug resistant bacteria. Here we discuss nanoparticles therapeutics and nano-drug delivery against bacterial infections. The therapeutic efficacy of numerous kinds of nanoparticles including nanoantibiotics conjugates, small molecules capped nanoparticles, polymers stabilized nanoparticles, and biomolecules functionalized nanoparticles has been discussed. Moreover, nanoparticles-based drug delivery systems against bacterial infections have been described. Furthermore, the fundamental limitation of biocompatibility and biosafety of nanoparticles is also conferred. Finally, we propose potential future strategies of nanomaterials as antibacterials.physical strength, electrical conductance, chemical reactivity and optical effects [11]. These criteria help in increasing the surface area, enhancing release of drug, reducing the dose required, and improving solubility and bioavailability of the compounds [12]. Moreover, these properties are also important for the diagnosis of microbial diseases with high sensitivity and selectivity and those with fluorescent properties or labeled with fluorescent dyes have also been employed for bacterial detection and susceptibility. In addition, inorganic nanoparticle-based diagnostic approaches depend upon the identification of known bacterial genome sequences by directing probes, and thus may not recognize altered and/or novel bacterial strains [13]. Furthermore, nanoparticles based specific drug targeting improve the therapeutic index, increase stability of drug, and decrease drug resistance. For example, silver nanoparticles affect Escherichia coli by forming complex with electron donor groups on amino acids and nucleic acids [12]. At present, liposomal drugs and polymer-drug conjugates have been approved for infectious diseases treatment, and many other antimicrobial nanoparticle formulations are under preclinical test [14].Gold nanoparticles have gained significant attention recently due to their tunable antimicrobial applications. Gold has been the subject of interest against bacterial infections for its biocompatibility and ease in conjugation with drugs and biomolecules. Gold conjugated with various drugs have shown to enhance their efficacy against bacteria. Gold nanoparticles coated with aminoglycosides have been found to be efficient antibacterial agents against various bacteria such as Staphylococcus aureus, Micrococcus luteus, E. coli and Pseudomonas aeruginosa [15]. In another study, after assessment of the surface chemistry of nanoparticles, the synergistic mechanism showed that hydrophobic cationic conjugated gold nanoparticles reduced the minimum inhibitory concentration (MIC) of fluoroquinolone against multidrug resistant by 8-16 times [16]. More recently, formulatio...

show abstract

Synthesis and Biomedical Applications of Multifunctional Nanoparticles

Cited by 234 publications

References 290 publications

Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

Advanced Bottom‐Up Engineering of Living Architectures

The Use of Nanomedicine for Targeted Therapy against Bacterial Infections

Contact Info

Product

Resources

About