Synthesis and Biological Properties of Novel Triazole-Thiol and Thiadiazole Derivatives of the 1,2,4-Triazole-3(5)-one Class

Synthesis of new 1,2,4-triazole compounds containing Schiff and Mannich bases (morpholine) with antioxidant and antimicrobial activities

“…The studies on the biological activities of Schiff and Mannich bases with different functional groups, including triazole and triazole-thiol, are available in the literature 31 . Not only triazole or triazole-thiol groups alone are effective in the antioxidant potential, but also the groups added to the structure significantly affect the activity in antioxidant activity evaluations of these bases with many antioxidant test methods, including DPPH and ABTS radical scavenging and FRAP 32 .…”

UV SPECTROPHOTOMETRIC DETERMINATION OF pK's OF 1,2,4-TRIAZOLINE-3-THIONES IN SODIUM HYDROXIDE SOLUTIONS

“…The T3T dissociation constants in sodium hydroxide media were calculated using the equation (2). Furthermore, the dissociation constants were determined graphically as an intercept of the plot of log I vs. pH values (Fig.…”

“…It is known that the thione form of 1,2,4-triazole-3-thiones were important for their antifungal activity. 2 Motivated by the significant importance and colossal interest for these types of compounds, during the last ten years, we synthesize and investigate a number of new 1,2,4-triazole derivatives [9][10][11] . Triazole derivatives act as weak bases in acidic media 12 .…”

“…The 1,2,4-triazole core is related with diverse biological activities such as: antimicrobial, hypoglycemic, anti-inflammatory, anticancer, fungicidal, anticonvulsant, diuretics and antibacterial properties [1][2][3] . Furthermore, 1,2,4-triazole derivatives have found broad use in the agriculture and chemical industry because of their herbicidal, insecticidal and fungicidal characteristics 2,4 . Some of the triazole derivatives can be used as industrial dyes, agrochemicals, photographic materials emulgators and corrosion inhibitor for copper [5][6][7][8] .…”

Synthesis and Antimicrobial Evaluation of Thieno[2,3-<i>d</i>]-pyrimidine, Thieno[2′,3′:4,5]pyrimido[1,2-<i>a</i>][1,3,5]triazine, Thieno[2,3-<i>d</i>]-1,3-thiazine and 1,2,4-Triazole Systems

“…11) Triazoles, in particular, substituted 1,2,4-triazoles are among the various heterocycles that have received the most attention during the last decades as potential antimicrobial agents. [12][13][14] In spite of a large number of antibiotics and chemotherapeutics available for medical usage, the increasing demands make it necessary to continue the search for new antimicrobial substances. Though, various molecules were designed and synthesized for this aim, the efforts have demonstrated that 1,3-diazines and 1,2,4-triazoles could be considered as possible antimicrobial agents.…”