Synthesis and Antimicrobial Evaluation of Thieno[2,3-<i>d</i>]-pyrimidine, Thieno[2′,3′:4,5]pyrimido[1,2-<i>a</i>][1,3,5]triazine, Thieno[2,3-<i>d</i>]-1,3-thiazine and 1,2,4-Triazole Systems

Utility of Lauroyl Isothiocyanate as a Scaffold in the Synthesis of Some Novel Pyrimidine Derivatives and Their Antimicrobial Assessment

“…These centers allow them to react with a variety of compounds via cyclization reactions to give fused heterocyclic compounds. [1][2][3][4][5][6][7][8][9][10] In addition, isothiocyanates containing -N=C=S functional group that is of immense importance in organic synthesis strategies. Furthermore, the presence of carbonyl group in acyl isothiocyanates imparts unique reactivity to them; leading to the synthesis of biologically important heterocyclic skeletons such as thiazoles, benzimidazoles, triazoles, dithiolane, thiadiazoles, pyrimidines, fused pyrimidines, fused oxazolines, triazines, and oxazines.…”

“…Furthermore, the presence of carbonyl group in acyl isothiocyanates imparts unique reactivity to them; leading to the synthesis of biologically important heterocyclic skeletons such as thiazoles, benzimidazoles, triazoles, dithiolane, thiadiazoles, pyrimidines, fused pyrimidines, fused oxazolines, triazines, and oxazines. [10][11][12][13][14][15][16][17] Pyrimidine and fused pyrimidine derivatives are a class of important heterocycles that have attracted considerable attention due to their therapeutic and pharmacological properties such as anticancer, 18,19) antiviral, 20) antihypertensive, 21) analgesic, 22,23) antiinflammatory, 24) antifungal and antibacterial. 25) In the light of previous observations and benefits, and in continuation of our previous work [10][11][12] in developing synthetic strategies for synthesis of fused heterocyclic compounds, lauroyl isothiocyanate reacted with a starting material containing enaminonitrile moiety to give polynuclear heterocyclic compounds containing pyridazine, thiophene, pyrimidine, benzimidazole, 1,2,4-triazole, 1,3,5-triazine and 1,3-oxazine rings.…”

Use of Phthalimidoacetyl Isothiocyanate as a Scaffold in the Synthesis of Target Heterocyclic Systems, and Their Antimicrobial Assessment

“…Simultaneous or subsequent cyclization of the obtained adducts gave target heterocyclic systems such as 1,2,4-triazoles, 1,3-diazines, 1,3-oxazines and thiourea attached to a phthalimido moiety. The antimicrobial activity of the synthesized compounds was tested.Key words phthalimidoacetyl isothiocyanate; 1,2,4-triazol; 1,3-diazine; 1,3-oxazine; thiourea; antimicrobial are well known.In the past few years the authors have been involved in the uses of aroyl isothiocyanates [17][18][19][20] and acyl isothiocyanates [21][22][23][24] in different synthetic strategies of target heterocycles. Studies on the chemistry of aroyl and/or acyl isothiocyanates have established the value of these compounds as starting materials in the synthesis of a wide variety of heterocyclic systems and thiourea derivatives.…”

“…In the past few years the authors have been involved in the uses of aroyl isothiocyanates [17][18][19][20] and acyl isothiocyanates [21][22][23][24] in different synthetic strategies of target heterocycles. Studies on the chemistry of aroyl and/or acyl isothiocyanates have established the value of these compounds as starting materials in the synthesis of a wide variety of heterocyclic systems and thiourea derivatives.…”

“…Studies on the chemistry of aroyl and/or acyl isothiocyanates have established the value of these compounds as starting materials in the synthesis of a wide variety of heterocyclic systems and thiourea derivatives. [17][18][19][20][21][22][23][24][25][26][27] Based on the previous work, we have been synthesized variety of heterocyclic systems bearing phthalimido moiety by using 2-phthalimidobenzoyl isothiocyanate 19) and phthalimidoacyl isothiocyanate. 22) In the current study, a further stage reactions of phthalimidoacetyl isothiocyanate was performed.…”