Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Yu, V. К.; Ten, Assel; Baktybayeva, L. K.; Sagatbekova, Indira; Praliyev, K. D.; Zolotareva, Darya; Сейлханов, Т. М.; Zazybin, Alexey

doi:10.1155/2018/7346835

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…This has prompted us to prepare a series of new structural analogs of these lead compounds and evaluate them pharmacologically to assess their antiviral and antitumor potential. The results are reported in this paper 5 .…”

Section: Introductionmentioning

confidence: 72%

A Review on the Some Biological Activities of the Hydantoin Derivatives

Wadghane

Bhor²,

Shinde³

et al. 2023

J. Drug Delivery Ther.

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Hydantoin derivatives are commonly used anticonvulsants. In general, they are effective for partial-onset seizures and tonic-clonic seizures, but not for absence seizures. Phenytoin is the most important drug in this group, and other drugs, ethotoin, and mephenytoin, are also commonly used to treat epilepsy. Prodrugs such as derivatives have been created. Phenytoin is effective in some cases of trigeminal neuralgia and related neuralgia. Phenytoin is also used to treat arrhythmias. Hydantoins or glycolylureas are heterocyclic organic compounds with the formula CH2C(O)NHC(O)NH. It is a colorless solid formed by the reaction of glycolic acid and urea. It is an oxidized derivative of imidazolidine. In a more general sense, hydantoins can refer to groups and classes of compounds that share the same ring structure as their parent. For example, phenytoin (see below) has two phenyl groups substituted at the 5th carbon of the hydantoin molecule. Actual chemotherapy for epilepsy dates back to the 1850s when "inorganic bromides" were introduced. However, it is worth noting that around the 1920s, the therapeutic and beneficial use of 'phenobarbital' usheredin an era of meaningful treatment of epilepsy. Hydantoin ring chemistry is the synthesis of rings by various methods and their applications in the medical field. Previous descriptions of hydantoin-containing compounds have broad pharmacological and biological activities, including anticancer, anti-inflammatory, anti-immune, antimetabolite, antioxidant, antibacterial, CNS-related, anticonvulsant, antitussive, and cytoprotective activities. Keywords: Hydantoin derivatives, anticonvulsants, partial-onset seizures and tonic-clonic seizures

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Section: Introductionmentioning

confidence: 72%

A Review on the Some Biological Activities of the Hydantoin Derivatives

Wadghane

Bhor²,

Shinde³

et al. 2023

J. Drug Delivery Ther.

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“…Recently it was found that some of the compounds exhibiting mielostimulating activity [14,15] also show growth stimulating activity [16], moreover, most of these ionic compounds were found to be non-toxic towards A. Fischeri which make them promising sustainable and environmentally friendly growth stimulants. Herein we report about the synthesis and growth regulating activity of new ionic compound obtained via N-alkylation of trimecaine.…”

Section: Introductionmentioning

confidence: 99%

Conventional and Nonconventional Methods of Synthesis and Growth-Stimulating Activity of 3-Chloro-N,n-Diethyl-N-(2-(Mesitylamino)-2-Oxoethyl)propan-1-Aminium Iodide

Dauletbakov¹,

Belyankova²,

Tursynbek³

et al. 2021

Chem. J. of Kaz.

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Synthesis of 3-chloro-N,N-diethyl-N-(2-(mesitylamino)-2-oxoethyl)propan-1-aminium iodide (1) was performed by via N-alkylation in conventional conditions and using microwave irradiation and ultrasound activation. The synthesized ionic compound was characterized using IR, 1H and 13C NMR, growth-stimulating activity had been tested for ten varieties and hybrids of sweet sorghum seeds.

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