2009
DOI: 10.1016/j.jfluchem.2009.08.001
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Synthesis and biological evaluation of triazepane derivatives as DPP-IV inhibitors

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Cited by 13 publications
(4 citation statements)
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“…[ 35,36 ] Triazepine derivatives have the ability to inhibit the dipeptidyl peptidase IV (DPP‐IV) and treatment of diabetes. [ 37 ] In addition, 1,2,4‐triazepines have many biological activities like renal vasodilator, salidiuretic, analgesic, antioxidant, and immunomodulating activities. [ 35,38 ] The fusion of triazepine to the pyrimidine moiety increases the improvement of the biological activity.…”
Section: Introductionmentioning
confidence: 99%
“…[ 35,36 ] Triazepine derivatives have the ability to inhibit the dipeptidyl peptidase IV (DPP‐IV) and treatment of diabetes. [ 37 ] In addition, 1,2,4‐triazepines have many biological activities like renal vasodilator, salidiuretic, analgesic, antioxidant, and immunomodulating activities. [ 35,38 ] The fusion of triazepine to the pyrimidine moiety increases the improvement of the biological activity.…”
Section: Introductionmentioning
confidence: 99%
“…Compound 131 was further converted to the final compound 133 through compound 132 or directly. Most of the synthesized compounds with the acid moiety showed potent inhibitory activity of dipeptidyl peptidase‐IV (DPP‐IV) without inhibiting CYP 3A4 (Scheme ) …”
Section: Discussionmentioning
confidence: 99%
“…Park et al prepared a series of triazepane derivatives and evaluated their DPP‐4 inhibitory action. Of all the synthesized derivatives, compound 73 ((( R )‐4‐[1‐acetyl‐2‐{3‐amino‐4‐(2,4,5‐trifluorophenyl)butanoyl‐1,2,5‐triazepan‐5‐carbonyl}benzoic acid])) was found to be highly potent DPP‐4 inhibitor with IC 50 value of 98 nM.…”
Section: Dpp‐4 Inhibitors Actionmentioning
confidence: 99%