Synthesis and biological evaluation of α-methylidene-δ-lactones with 3,4-dihydrocoumarin skeleton

Lactones 46. Synthesis, antifeedant and antibacterial activity ofγ-lactones with ap-methoxyphenyl substituent

“…Lactones with a p ‐menthane system have exhibited activity against stored‐product pests, aphids, lesser mealworm and Colorado potato beetle . Additionally, this group of compounds is known for a wide spectrum of antibacterial activity . They can have different mechanisms of action, for example inhibition of bacterial growth or reduction in biofilm formation .…”

Proteomic Analysis of Proteins Engaged in α‐Methylene‐δ‐Lactone Cytotoxic Effects in Hormone‐Independent Breast Cancer MDA‐MB‐231 Cells

“…A number of synthetic compounds with a-methylene-c-lactone skeleton have also been published. However, biological evaluation of these potential anticancer agents is limited mostly to assessing their cytotoxic activity against selected cancer cell lines (16,17).…”

Syntheses and Biological Activities of Chroman-2-ones. A Review

“…33 Several 3-methylidene chroman-2-ones (19, R 1 = H, OMe; R 1 , R 2 = -CHCHCHCH, -CHC(OH)CHCH; R 2 = H; R 2 , R 3 = -CH 2 OCH 2 -; R 3 = OMe, H; R 4 = Me, n-Bu, i-Pr, vinyl) showed potent cytotoxic activity on screening against several cancer cell lines with IC 50 values below 1 μM and exhibited interesting structure-activity relationships. 34 Neoflavonoids, including some of the 3,4-dihydro-4-aryl-coumarin derivatives 4-7, display pharmacological properties, such as bactericidal, 35 molluscicidal 36 and insecticidal. 37 Cortez and co-workers demonstrated that 5,7-dihydroxy-8-(2-methylbutanoyl)-6-(3-methylbutyl)-4-phenyl-chroman-2-one 20 prepared by hydrogenation of mammea A/BB coumarin exhibited greater anti-leishmanial activity than mammea A/BB coumarin.…”