Lactones 46. Synthesis, antifeedant and antibacterial activity ofγ-lactones with ap-methoxyphenyl substituent

Abstract

The results of biological tests showed that halogen atom removal significantly increased the antifeedant properties of γ-lactones with a p-methoxyphenyl substituent. Unsaturated lactones are most promising in the context of their possible industrial application as crop protection agents. Further structural modifications of lactones with aromatic rings are needed to find important structural factors increasing the antibacterial activity.

Crucial role of oxidative stress in bactericidal effect of parthenolide against Xanthomonas oryzae pv. oryzae

“…Therefore, novel bactericides are needed as alternative control agents. Lactones are well known for their biological activities, including anti‐bacterial activity . PTL is a sesquiterpene lactone well known for its anti‐tumor and anti‐inflammatory activities, and it also has shown inhibitory activities against phytopathogens .…”

“…Lactones are well known for their biological activities, including anti-bacterial activity. 27 PTL is a sesquiterpene lactone well known for its anti-tumor and anti-inflammatory activities, and it also has shown inhibitory activities against phytopathogens. [18][19][20] In the preliminary study, we assayed the anti-microbial activities of PTL against 11 plant-pathogenic fungi, three plant-pathogenic oomycetes, wileyonlinelibrary.com/journal/ps and three plant-pathogenic bacteria at 10 mg L −1 in vitro, and found that PTL was most effective against Xoo (data not shown).…”

Chemoenzymatic Synthesis of Enantiomeric, Bicyclic δ-Halo-γ-lactones with a Cyclohexane Ring, Their Biological Activity and Interaction with Biological Membranes

“…The natural lactones isolated from fruits and essential oils can be used as fragrance components, like jasmine lactone or as a flavor in the food industry (δ-decalactone) [1][2][3]. Those compounds can also be pheromones [4,5] or antifeedants [6][7][8] but the largest interest is put in their antimicrobial and cytotoxic potential. There are numerous examples presenting the antibacterial and antifungal activity of lactones [8,9].…”

Magnetic Fe3O4@poly(propylene fumarate-co-ethylene glycol) core–shell biomaterials

“…Another potential reason for the antimicrobial action observed herein is the presence of non-reacted NHS esters, since lactones are known to have a wide spectrum of antimicrobial effect. 73 To verify this, the antibacterial activity of the NHS-activated P(PF-co-EG) network was also tested, and it was found to exhibit higher biocide action than the neat copolymer (i.e. in the range of 0.60-0.75 and 0.25-0.40 against Gram-negative and Gram-positive bacteria, respectively).…”