Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives

Chandrakantha, B.; Isloor, Arun M.; Shetty, Prakash; Fun, Hoong‐Kun; Hegde, Gurumurthy

doi:10.1016/j.ejmech.2013.10.056

Cited by 58 publications

(38 citation statements)

References 27 publications

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“…This simple route to 2-amino 5-substituted-1,3,4-thiadiazole seems to be quite general 18 . In the example shown R may be methyl 18 , norhydnocarpyl 19 , benzyl 20 , cyclopropyl 21 and many others.…”

Section: Recent Strategies In the Synthesis Of 1 3 4-thiadiazolesmentioning

confidence: 99%

“…The compounds (19a-c) showed high inhibitory effect towards tested fungi 95 . Biological studies of bis thiadiazole/triazole (20) by sonication as potential antibacterial activity using standard drug Ampicillin Trihydrate at concentration 50μg/ml 96 .…”

Section: Antimicrobial and Antifungal Activitymentioning

confidence: 99%

“…They have known to exhibit diverse biological activities such as in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities 3 . New acylated 5-thio-beta-D-glucopyranosylimino-disusbstituted 1,3,4-thiadiazoles prepared by cycloaddition of the glycosyl isothiocyanate with the reactive intermediates 1-aza-2-azoniaallene hexachloro antimonates, and have been tested in vitro antiviral activity against HIV-1, HIV-2, human cytomegallovirus (HMCV) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

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Chemistry, synthesis and progress report on biological activities of thiadiazole compounds - a review

Asif¹

2016

Mediterr.J.Chem.,

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Thiadiazoles are an important class of heterocyclic compounds that exhibit diverse applications in organic synthesis, pharmaceutical and biological applications. They are also useful as oxidation inhibitors, cyanine dyes, metal chelating agents, anti-corrosion agents. Researchers across the globe are working on this moiety due to their broad spectrum of applications of thiadiazole chemistry. This article provides information about developments, exploration, synthetic strategies, techniques for the synthesis of thiadiazoles and their diverse biological activities, structure-activity relationship of the compounds and physical properties. This article is an important tool for organic and medicinal chemists to develop newer thiadiazole compounds that could be better agents in terms of efficacy and safety.

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Section: Recent Strategies In the Synthesis Of 1 3 4-thiadiazolesmentioning

confidence: 99%

Section: Antimicrobial and Antifungal Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemistry, synthesis and progress report on biological activities of thiadiazole compounds - a review

Asif¹

2016

Mediterr.J.Chem.,

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“…Graphical Abstract Synthesis of compounds 2-27. R: 2,5,7,10,13,[15][16][17][18][19][20][21][22][23][24][25][26][27]3,8,4,9,12 …”

mentioning

confidence: 99%

Synthesis and biological activity of 1,3,4-oxa(thia)diazole, 1,2,4-triazole-5-(thio)one and S-substituted derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid

et al. 2015

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A series of novel derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid bearing two identical substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole, or 1,2,4-triazole moieties were synthesized and their molecular structures were confirmed by IR, 1 H, 13 C NMR spectroscopy, and elemental analysis data. The synthesized compounds were screened for their reducing power, free radical scavenging, plant growth regulating, and antimicrobial properties. 5,5 0 -((Phenylazanediyl)bis(ethane-2,1-diyl))bis(4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione) showed excellent antioxidant activity, three times higher than that of the antibiotic control (cefazolin). 2,2 0 -((((Phenylazanediyl)bis(ethane-2,1-diyl))bis(4-phenyl-4H-1,2,4-triazole-5,3-diyl))bis(sulfanediyl))diacetate exhibited notable bactericidal activity against Pseudomonas aeruginosa with MBC and MIC values 7.3 lg/ml, whereas 12 compounds displayed significant fungicidal activity against Candida albicans with MIC value 3.9 lg/ml. Graphical Abstract Synthesis of compounds 2-27. R: 2,5,7,10,13,[15][16][17][18][19][20][21][22][23][24][25][26][27]3,8,4,9,12

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“…1,3,4-Thiadiazoles are an important class of heterocyclic bioactive compounds with a broad range of biological activities such as antioxidant, 5,6) antibacterial, 7,8) antidepressant, 9,10) antidiabetic, 11,12) antifungal, 13,14) anticonvulsant, 15,16) anti-inflammatory, 17,18) anticholinesterase, 19) antileishmanial, 20) inhibition of human protoporphyrinogen oxidase. 21) In particular, a large number of 1,3,4-thiadiazole derivatives display interesting antitumour activities in vitro and in vivo conditions.…”

mentioning

confidence: 99%

Design, Synthesis and Antiproliferative Evaluation of Novel Disulfides Containing 1,3,4-Thiadiazole Moiety

Zhang

Liu

Tang

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Synthesis and biological evaluation of novel substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1-b] [1,3,4] thiadiazole derivatives

Cited by 58 publications

References 27 publications

Chemistry, synthesis and progress report on biological activities of thiadiazole compounds - a review

Chemistry, synthesis and progress report on biological activities of thiadiazole compounds - a review

Synthesis and biological activity of 1,3,4-oxa(thia)diazole, 1,2,4-triazole-5-(thio)one and S-substituted derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid

Design, Synthesis and Antiproliferative Evaluation of Novel Disulfides Containing 1,3,4-Thiadiazole Moiety

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