Design, Synthesis and Antiproliferative Evaluation of Novel Disulfides Containing 1,3,4-Thiadiazole Moiety

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review

“…Compounds 78 , 80 and 82 demonstrated high antiproliferative activities against SMMC-7721 cells with IC 50 values of 2.54, 2.69 and 2.31 μM ( Figure 43 ). All the tested compounds showed a weak cytotoxic effect against the normal cell line L929 [ 50 ].…”

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

“…= 247.6 -249.9 °C, 1 H-NMR (300 MHz, DMSO-d 6 ): 0.88 (3H, t, J=7.4 Hz, -CH 3 ), 1.54 (2H, q, J=7.11 Hz, -CH 2 -), 3.18 (2H, q, J=5.55 Hz, -CH 2 -), 4.00 (2H, s, -CH 2 -), 7.76 (1H, br.s., -NH). 13…”

“…The final compounds were purified, and their structures were characterized by spectroscopic methods ( 1 H-NMR, 13 C-NMR, and LC-MS/MS). In the 1 H NMR spectrum, monosubstituted benzene protons had triplet and doublet peaks between 6.98 ppm and 7.56 ppm.…”

“…In addition to structure elucidations using routine spectroscopic methods, 2D NMR studies including 1 H- 13 C HMBC and 1 H-13 C HSQC were performed for compound 4a, as seen in Figure 1 information obtained in the HSQC, the peak at 31.49 ppm belongs to the methyl carbon and the peak at 38.86 ppm belongs to the methylene carbon. HMBC shows interactions between hydrogen and carbon at a distance of 2 to 4 bonds.…”

“…The potential anticancer activity of this structure is one the most interesting areas that have encouraged researchers to focus on it. Hence, a large number of 1,3,4-thiadiazole derivatives have been synthesized and their molecular mechanism of anticancer activity has been investigated [10][11][12][13][14][15].…”