Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

Abstract

Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

Antioxidant properties, anti- SARS-CoV-2 study, collagenase and elastase inhibition effects, anti-human lung cancer potential of some phenolic compounds

“…After these interactions patterns, ADME/T calculations were made to examine how these molecules act in human metabolism. With these calculations, he examines the uptake of molecules into human metabolism, their movements for metabolism, their effects and reactions, and finally their excretion from human metabolism [ 43 , 44 ].…”

Design, Synthesis, Molecular Docking, ADME and Biological Evaluation Studies of Some New 1,3,4-oxadiazole Linked Benzimidazoles as Anticancer Agents and Aromatase Inhibitors

“…The anticancer activity of compounds 5a-5f was screened according to the MTT assays. The MTT assays were performed as previously described [19][20][21]. Anticancer activity of nal compounds was assessed against ve different cancer cell lines A549 (lung carcinoma cell line), HeLa (cervical cell line), MCF-7 (human breast adenocarcinoma cell line), HepG2 (human liver carcinoma cell line), and C6 (rat glioma cell line) cell lines as well as NIH3T3 (mouse embryo broblast cell line).…”

Titrimetric and Spectrophotometric Determination of Some Thiadiazole Derivatives by Using Amplification Reactions

“…Kaur and Sing [12] published a review on the Thiadiazole analogs as potential pharmacological agents. Thiadiazole derivatives are utilized therapeutically for various diseases thanks to their antiviral [13], anticonvulsant [14] anti-inflammatory [15], anticancer [16] activities. It was also reported that thiadiazole derivatives demonstrated antithyroid activities [17].…”