Synthesis and Biological Evaluation of Quinoline‐Based Novel Aurones

Kumar, Gourav; Lathwal, Ekta; Saroha, Bhavna; Kumar, Sanjeev; Kumar, Suresh; Chauhan, Nar Singh; Kumar, Tarun

doi:10.1002/slct.201904912

Cited by 51 publications

(23 citation statements)

References 39 publications

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“…In particular, enlargement of the aromatic area in this position, as in derivatives 10 and 11 ( Figure 3 ), provided the most performing compounds, showing minimal inhibitory concentrations (MICs) in the micromolar/submicromolar range against several pathogen bacteria. Similar functional results were also achieved when the benzofuranone core was replaced with the bioisosteric indolone, as in derivative 12 ( Figure 3 ) [ 20 , 21 , 22 ].…”

Section: Aurones As Functional Agentssupporting

confidence: 63%

Aurones: A Golden Resource for Active Compounds

2021

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Deemed as poorly represented in nature, aurones have been often overlooked by researchers compared to other members of the flavonoid superfamily. However, over the past two decades, they have been reassessed by the scientific community, who are increasingly appreciating their ability to modulate several biological pathways. This review summarizes the recent literature on this class of compounds, which has been analyzed from both a chemical and a functional point of view. Original articles, reviews and editorials featured in Pubmed and Scifinder over the last twenty years have been taken into account to provide the readers with a view of the chemical strategies to obtain them, their functional properties, and their potential of technological use. The resulting comprehensive picture aims at raising the awareness of these natural derivatives as effective drug candidates, fostering the development of novel synthetic analogues.

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Section: Aurones As Functional Agentssupporting

confidence: 63%

Aurones: A Golden Resource for Active Compounds

2021

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“…52 As a member of the avonoid family, thus far aurones have been reported to possess different bioactivities including antitumor, anticancer, antioxidant, metal ion-chelating, antityrosinase, antiparasitic, antimicrobial, antiviral, anti-inammatory, anti-diabetic, anti-hormonal and anti-obesity activity. 53 They have been found to act as inhibitors for several enzymes such as monoamine oxidase A and B, histone deacetylase and cyclin-dependent kinase, 54 and thus represent an overwhelming and rapidly developing eld in modern heterocyclic chemistry. 55 Considering the literature ndings and in continuation of our previous studies 47,48 aimed at developing new molecules as potent biological candidates, herein, we report the design and synthesis of a new series of chalcones and aurones.…”

Section: Introductionmentioning

confidence: 99%

2-Benzylidenebenzofuran-3(2H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational studies

et al. 2021

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“…Recently our research group have also reported [49] a series of quinoline based aurones 77 ( a – n ) by treating 2‐chloro‐1‐(2,4‐dihydroxyphenyl)ethan‐1‐one 75 with different 2‐chloroquinoline‐3‐carbaldehydes 76 ( a – n ) in presence of activated barium hydroxide (Scheme 17). The synthesized derivatives were investigated for anti‐biofilm, anti‐fungal and anti‐bacterial activities.…”

Section: Synthesis and Biological Assessmentsmentioning

confidence: 99%

Recent Advances in Synthesis and Biological Assessment of Quinoline‐Oxygen Heterocycle Hybrids

et al. 2021

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The exploration of hybrid molecules for targeting various diseases represents a highly promising approach which has showcased significant momentum worldwide, in the last two decades. Diversely substituted quinoline scaffolds present in naturally occurring bioactive compounds, signify their role in various biological processes and stimulated the research developments around it, for diverse therapeutic applications. With the ongoing search for suitable pharmacophores, the quinoline derivatives have emerged as versatile compounds possessing significant and broad spectrum of biological activities. Further, conjugation of quinoline with other bioactive heterocycles containing oxygen yielded hybrid organic frameworks with improved therapeutic profile leading to an emerging paradigm and tremendous growth in the contemporary drug discovery regime. The synthesis of these hybrid skeletons with high efficiency still remains the most strenuous task and a lot of research work is being performed in this direction. In the present article, we have reviewed the synthetic protocols leading to quinoline‐oxygen heterocycle hybrids and also highlighted the systematic and biological assessment of developed pharmacophores.

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Synthesis and Biological Evaluation of Quinoline‐Based Novel Aurones

Cited by 51 publications

References 39 publications

Aurones: A Golden Resource for Active Compounds

Aurones: A Golden Resource for Active Compounds

2-Benzylidenebenzofuran-3(2H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational studies

Recent Advances in Synthesis and Biological Assessment of Quinoline‐Oxygen Heterocycle Hybrids

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