Nanographenes have been attracting increasing attention owing to their widespread applications in organic electronics. Polycyclic aromatic hydrocarbons are popular research subjects due to their high stability, planar structure and optical spectra.

This review revealed that among all the natural and synthetic flavonoids, the inhibitory findings suggest that the flavonol moiety can serve as an effective and a lead structural scaffold for the further development of novel TIs.

Anthraquinones are privileged chemical motifs with diverse therapeutic applications, especially in the treatment of cancer. The extensive literature highlights the significance of anthraquinones as potent anticancer agents.

DDQ is the most widely used quinone with a high reduction potential and it mediates hydride transfer reactions and shows three accessible oxidation states: quinone (oxidized), semiquinone (one-electron-reduced) and hydroquinone (two-electron-reduced).

Aurones are the plant secondary metabolites belonging to the flavonoid’s family. The bioactivities of aurones are very promising, thus these heterocyclic compounds can be considered as an alluring scaffold for drug design and development.

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In this study, a new series of 2,7-dichloro-4-(2-substituted-amino acetyl)fluorene derivatives were synthesized, characterized and evaluated for their antimicrobial activity and screened for cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines. Most of the synthesized compounds displayed significant activity against A-549 and MCF-7 cell lines when compared to 5-fluorouracil (5-FU), which was used as a reference drug. In addition, some of these reported novel compounds exhibited promising antibacterial and antifungal properties. A molecular docking study was performed to identify the mechanism of action of the synthesized compounds, which suggested binding interactions with the active sites of dihydrofolate reductase (DHFR).