Synthesis and Biological Evaluation of Some Pyrazole-based Mannich Bases

Alam, Faruk

doi:10.5958/0974-360x.2019.00726.1

Cited by 4 publications

(2 citation statements)

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“…The shampoo's power to clean is stronger the lower the surface tension. A shampoo is considered high-grade if it lowers the surface tension of pure water from 72.28 dyn/cm to around 40 dyn/cm 32 . All the shampoos put to the test displayed comparable surface tension reductions, ranging from 31.68 to 38.72 dyn/ cm (Table 3).…”

Section: The Physical Appearance Of All Formulations (F1-f5)mentioning

confidence: 99%

Development and Evaluation of Natural Anti-dandruff Shampoo

Alam,

Das,

Kalita

et al. 2023

JNR

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The purpose of the study was to develop a pure herbal anti-dandruff shampoo and assess its efficacy and safety. The herbal shampoo was prepared by mixing various amounts of the following extracts into a 10% aqueous solution: Neem (Azadirachta indica), Lemongrass (Cymbopogon citrates), Reetha (Sapindus mukorossi), Sheekakai (Sapindus indica), Amla (Indian gooseberries), Bhringaraj (Eclipta alba), and Brahmi (Bacopa monnieri). The pH was changed, and methylparaben was added as a preservative in very minute amounts. To ascertain the physicochemical characteristics of the prepared shampoos, several tests including visual inspection, pH, wetting time, percentage of solid contents, foam volume and stability, surface tension, detergency, dirt dispersion, etc. were carried out. By giving 20 student volunteers a blind test, the conditioning performance of the herbal shampoo formulation was also assessed. The herbal shampoo was presented simply and appealingly. It demonstrated high detergency, good cleaning, and low surface tension. After 5 minutes, the shampoo’s formulation provided good foam stability. It was discovered that the scores for the conditioning performance of the hair after using a herbal shampoo ranged from 1.75 to 3.4. The results revealed that the specifically formulated shampoo had outstanding conditioning performance, comparable to a shampoo that is easily found in markets. Malassezia furfur was used as a test subject for the efficiency of the multi-herbal anti-dandruff formulations. Formulation F4 demonstrated strong antifungal activity, as measured by the zone of inhibition and lowest inhibitory concentration. However, additional research and development are required to improve its quality and safety.

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Section: The Physical Appearance Of All Formulations (F1-f5)mentioning

confidence: 99%

Development and Evaluation of Natural Anti-dandruff Shampoo

Alam,

Das,

Kalita

et al. 2023

JNR

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“…Mannich bases also act as vital pharmacophores which are employed for the preparation of different therapeutic agents holding the group of aminoalkyl chains [19]. They offered various pharmacological benefits, such as anti-inflammatory [20], anticancer [21], antipyretic [22], antibacterial [23], anti-fungal [24], anthelmintic [25], anticonvulsant [26], analgesic [27], antitubercular [28], anti-HIV [29], antimalaria [30], antiviral agent [31], antipsychotic [32], etc. Some of the medicinal compounds having Mannich base are fluoxetine, atropine and ranitidine, etc.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Characterization and Antitubercular Activity of Novel Benzimidazole Mannich Base Derivatives

Gopi,

Dhanaraju,

Pranusha

et al. 2024

ajc

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In present work, the newly synthesized benzimidazole Mannich base derivatives were design, synthesized and evaluated the in silico and in vitro antitubercular activity. These compounds were synthesized by condensation reaction between 1-(1H-benzo[d]imidazol-1-yl)ethanone and aliphatic/aromatic amines. The synthesized compound structures were identified by FTIR, 13C NMR, 1H NMR and mass spectroscopies. The results indicated that these derivatives have significant antitubercular activity against Mycobacterium tuberculosis (M.tb) cell wall enzyme enoyl acyl carrier protein reductase (InhA), EthR regulatory protein in H73Rv strain. The results found in the in vitro study are firmly similar to the in silico study. Among the synthesized compounds, 3d and 3e exhibited the highest activity due to the connection of the electron-donating group to the Mannich base. Therefore, these compounds deserve the development of new antitubercular agents.

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Synthesis and Biological evaluation of some newer Pyrazole Derivatives

Sharma

Chopra

2021

RJPT

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Pyrazoline is a 5-membered heterocyclic moiety has two adjoining nitrogen iotas and three carbon particles inside the ring. Pyrazoline subordinate are related wide scope of pharmacological and restorative exercises, for example, antibacterial, antifungal, pain relieving, calming, hostile to parasitic, against malarial, against oxidant. The ongoing work of exploration is fundamentally engaged at the revelation and improvement of a progression of 1,3,5-trisubstituted pyrazoline. A progression of new 1-phenyl-3-(4-nitrophenyl)- 5-(subbed phenyl) pyrazoline subordinates (2a-2j) were blended by the response of subbed acetophenone and subbed benzaldehyde within the sight of fluid sodium hydroxide arrangement by Claisen Schmidt buildup system. The subbed chalcone were integrated which is additionally dense with phenyl hydrazine in ethanol and results in the definition of conclusive subordinates of pyrazoline (2a-2j). The response blend was observed by TLC and the last mixes were refined by recrystallization from wanted dissolvable. All the structures of blended mixes were affirmed by FTIR, 1H NMR, mass unearthly information and essential investigation. All the recently combined mixes (2a-2j) were assessed for antibacterial and antifungal movement. Mixes 2f, 2i and 2h showed powerful inhibitory impact against on strains of both bacterial and parasitic species.

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Synthesis and Biological Evaluation of Some Pyrazole-based Mannich Bases

Cited by 4 publications

References 0 publications

Development and Evaluation of Natural Anti-dandruff Shampoo

Development and Evaluation of Natural Anti-dandruff Shampoo

Design, Synthesis, Characterization and Antitubercular Activity of Novel Benzimidazole Mannich Base Derivatives

Synthesis and Biological evaluation of some newer Pyrazole Derivatives

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