Synthesis and Biological Evaluation of Novel Bis[1,2,4]triazolo[3,4-b] [1,3,4]oxadiazoles

Rapid, microwave accelerated synthesis of [1,2,4]triazolo[3,4- b ][1,3,4]oxadiazoles from 4-acylamino-1,2,4-triazoles

“…However, [1,2,4]triazolo[3,4- b ][1,3,4]oxadiazoles ( 1 ) are surprisingly under-investigated. In the few assays executed, compounds containing this moiety exhibited antibacterial activity similar to that of streptomycin, 19 herbicidal activity comparable to the commercially available 2,4-dichlorophenoxyacetic acid (2,4-D), and fungicidal activity akin to the commercial Dithane M-45. 20 Furthermore, in a library of oxadiazole derivatives screened for antimicrobial activity, the triazolo-oxadiazole was considered the most active.…”

“…In nearly all approaches to 1 the oxadiazole is first prepared and the triazole is formed in the final step. For instance, 1,3,4-oxadiazoles functionalized at the 2-position with acylhydrazines ( 2 ), 19,23-25 hydrazones ( 3 ), 26-27 and unsubstituted hydrazines ( 4 ) 20,28-29 can be directly converted to 1 via triazole cyclization. The triazole has also been formed by reacting hydrazine hydrate with either EtOH and amino oxadiazoles ( 5 ), 21 N -substituted oxadiazolines ( 6 ), 30 or N -acylated oxadiazolones ( 7 ).…”

Multicomponent One‐pot Synthesis of Oxadiazole Included Pyranopyrazoles as Promising Antioxidant Agents

“…Several biologically active oxadizoles have been reported previously [13,14]. Biotic capacities of oxadiazoles were also reported in the literature as anticancer [15,16], antiproliferative [17], anti-HIV [18], anti-inflammatory [19], antitubercular [20], antimicrobial [21][22][23], anticonvulsant [24], antimalarial [25], antihepatitis B viral activities [26], and many more.…”