Multicomponent One‐pot Synthesis of Oxadiazole Included Pyranopyrazoles as Promising Antioxidant Agents

Abstract

Oxadiazole‐fused combinations are of great concern for the novelty of effective therapeutic agents. In this context, a series of oxadiazole included pyranopyrazoles were prepared under eco‐friendly synthetic way by using montmorillonite k10 as a catalyst. All the final outcomes were formed with good yields. Further, compounds screened for their antioxidant assay. Most of the compounds revealed promising activity. Among all outcomes, electron rich‐substituted compounds at para position demonstrated higher antioxidant activity than their corresponding ortho‐substituted compounds. All belongings concluded that this eco‐friendly path is preferable to prepare therapeutic compounds. Further, biotic results established that all these biologically active compounds fit for supplementary to develop exogenous antioxidant drugs.

Synthesis, Characterization and Evaluation of Some Pyranopyrazole Derivatives as Multifunction Additives for Medium Lubricating Oils

“…Pyranopyrazoles are a fused system of heterocyclic compounds that contain pyran and pyrazol rings with biological activities [4]. Many pyranopyrazoles have been synthesized [5] and have been reported to be antimicrobial [6,7], antibacterial [8,9], anti-fungicidal [10], antiinflammatory [11], anticancer [12,13], and antioxidant [14,15]. Additionally, novel pyranopyrazole derivatives have been used as lubricating oil antioxidant additives [16].…”

A New Pathway for the Preparation of Pyrano[2,3-c]pyrazoles and molecular Docking as Inhibitors of p38 MAP Kinase

“…Pyranopyrazoles are some of the essential compounds in pharmacological chemistry. 1 − 3 Some of the great biological activities of the pyranopyrazole framework are anti-inflammatory, 4 − 6 anticancer, 7 − 9 antimicrobial, 10 antioxidant, 11 anticholinesterase, 12 analgesics, 5 and antimicrobial activity ( Scheme 1 ). 13 Generally, pyranopyrazoles have been synthesized from aldehydes, malononitrile, ethyl acetoacetate, and hydrazine derivatives through multicomponent reactions, which was one of the effective methods applied.…”

“…Pyranopyrazoles are some of the essential compounds in pharmacological chemistry. − Some of the great biological activities of the pyranopyrazole framework are anti-inflammatory, − anticancer, − antimicrobial, antioxidant, anticholinesterase, analgesics, and antimicrobial activity (Scheme ). Generally, pyranopyrazoles have been synthesized from aldehydes, malononitrile, ethyl acetoacetate, and hydrazine derivatives through multicomponent reactions, which was one of the effective methods applied. − Several protocols have been reported for using various catalysts such as nanoparticles, − organocatalysts (MDOs), Fe 3 O 4 @THAM-SO 3 H, Fe 3 O 4 @SiO 2 @CPTMO@DEA-SO 3 H, the water extract of banana peels, chitosan materials, nano-BF 3 /MNPs, nano-NH 4 H 2 PO 4 /Al 2 O 3 , disulfonic acid imidazolium chloroaluminate ([Dsim]­AlCl 4 ), and solid catalysts …”

“…Sulfonated amorphous carbons have been studied extensively in catalysis, adsorbents, and electrochemistry. ,− In 2004, Hara and co-workers developed new catalysts, a carbon-based solid acids with sulfonic acid groups (SO 3 H). The sulfonated amorphous carbons were applied for organic syntheses such as esterification, − rearrangement, , C–C coupling reactions, condensations, , amidations, and amination. , …”

Synthesis of pyrano[2,3‐c]pyrazoles: A review

“…Dihydropyrano[2,3‐c]pyrazole 1 nucleus is a fruitful source of several medicinally important compounds because of its diverse bioactivities, such as anti‐inflammatory, [ 8,9 ] anticancer, [ 10–12 ] antioxidant, [ 13–15 ] anti‐cholinesterase, [ 16 ] analgesic, [ 9 ] antimicrobial activity, [ 17–20 ] and also act as human checkpoint kinase 1 (Chk1) inhibitor 5 (Figure 2). [ 21 ]…”