2020
DOI: 10.1007/s00706-020-02690-7
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Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents

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Cited by 6 publications
(12 citation statements)
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“…Similarly, ethyl containing bis(2,4,6-trinitrophenyl) alkane diamine derivative (comp. 12) in our previous study [13] were found moderately toxic on Hep3B, PC3, and HT-29 as a drug, butyl containing TNA6 derivative in this study showed good toxicity (IC 50 : 2.809 μM) on Hep3B as a prodrug. In addition, prodrugs TNA4-5 and TNA7 were also found more effective than CB1954 at intracellular Hep3B conditions.…”
Section: Intracellular Reaction Assays Of Ssap-ntrb and Prodrug Candidatessupporting
confidence: 60%
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“…Similarly, ethyl containing bis(2,4,6-trinitrophenyl) alkane diamine derivative (comp. 12) in our previous study [13] were found moderately toxic on Hep3B, PC3, and HT-29 as a drug, butyl containing TNA6 derivative in this study showed good toxicity (IC 50 : 2.809 μM) on Hep3B as a prodrug. In addition, prodrugs TNA4-5 and TNA7 were also found more effective than CB1954 at intracellular Hep3B conditions.…”
Section: Intracellular Reaction Assays Of Ssap-ntrb and Prodrug Candidatessupporting
confidence: 60%
“…Chemistry Some trinitroaniline derivatives (TNA1-8) as nitro group containing prodrug candidates were synthesized in different ways and characterized with various spectral techniques (FT-IR, 1 H NMR, 13 C NMR, and MS) in this study (Figure 1, 2 and Supporting Information). Different functional groups were used for the target compounds and investigated their prodrug ability through enzymatic and cytotoxic activity studies.…”
Section: Resultsmentioning
confidence: 99%
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