“…So, their detailed cytotoxic activity studies, including cell cycle progression, apoptosis, metastatic effect, and cancer drug abilities, were investigated. [13] Prodrugs TNA1-5 were synthesized from picryl chloride and aliphatic, aromatic, or heterocyclic amines (cyclohexylamine, benzylamine, 2,4-dinitroaniline, piperidine, and morpholine) using different bases (Et 3 N, NaHCO 3, or K 2 CO 3 ) via aromatic nucleophilic substitution reaction with mild yields, 38-78 % (Figure 1). As revealed in Figure 2, prodrugs TNA6-8 were obtained from picryl chloride and diaminoalkane derivatives (1,4-diaminobutane, 1,3-diaminocyclohexane, and 1,4-diaminocyclohexane) using triethylamine as a base at room temperature for 6-24 h with high yields (72-93 %).…”