Synthesis and Biological Evaluation of Some Pyrrolidine-2-one Derivatives

Abstract

In this research a number of pyrrolidine-2-one derivatives were prepared by lactamization of γ –butyrolactone (GBL) with hydrazine hydrate (80%) to produce (1-aminopyrrolidine-2-one) that undergoes several reactions to afford these derivatives that diagnosed by infrared, nuclear magnetic resonance and mass spectroscopy. Antibacterial activity has also been studied using some types of bacteria, some were found to have good antibacterial activity.