Synthesis and biological evaluation of 3-aryloxyalkyl-6-aryl-7H-s-triazolo[3,4-b][1,3,4]thiadiazines

Potentiometric Determination of Pharmaceutically Important Nimesulide in Non-Aqueous Medium

“…Some of the present day drugs such as ribavirin (antiviral agent), rizatriptan (antimigraine agent), alprazolam (anxiolytic agent), fluconazole and itraconazole (antifungal agents) are the best examples for potent molecules possessing triazole nucleus [5][6][7] . Many literatures have shown that Mannich bases possess potent biological activities such as antibacterial, antifungal, anti-inflammatory, antimalarial and pesticide properties [8][9][10][11] . Few Mannich bases derived from 1,2,4-triazoles carrying N-methylpiperzine substituent were biologically active 12,13 .…”

A convenient synthesis and biological activities of novel 6‐aryl‐3‐(1,2,3,4‐tetrahydroxybutan‐1‐yl)‐7H‐1,2,4‐triazolo‐[3,4‐b][1,3,4]thiadiazines

“…They can also be used as plant growth inhibitors [4][5][6][7][8]. Our researches have been devoted for several years to the synthesis of a series of novel compounds -7H-1,2,4-triazolo [3,4-b] [1,3,4]thiadiazines [9][10][11][12]. However, we noticed that, besides our research in this respect, almost all of the substitutions at 3-, 6-and 7-positions in this kind of compounds, which are currently available are alkyl or aryl groups [13][14][15][16].…”

“…1,2,4-triazolo [3,4-b] [1,3,4]thiadiazines are condensed heterocyclic compounds having a wide range of applications. A literature survey showed that this kind of compounds combined the properties of triazoles and thiadiazines [1,2]; thereby some of them showed wide spectrum of biological activities, such as antimicrobial, antibacterial, antifungal, anti-inflammatory, diuretic, anthelmintic, analgesic and antiparasitic [3].…”

“…A literature survey showed that this kind of compounds combined the properties of triazoles and thiadiazines [1,2]; thereby some of them showed wide spectrum of biological activities, such as antimicrobial, antibacterial, antifungal, anti-inflammatory, diuretic, anthelmintic, analgesic and antiparasitic [3]. They can also be used as plant growth inhibitors [4][5][6][7][8]. Our researches have been devoted for several years to the synthesis of a series of novel compounds -7H-1,2,4-triazolo [3,4-b] [1,3,4]thiadiazines [9][10][11][12].…”

“…A series of novel 6-aryl-3-(1,2,3,4-tetrahydroxybutanol-1-yl)-7H-1,2,4-triazolo [3,4-b] [1,3,4]thiadiazines were easily synthesized in high yields by means of the reactions of 4-amino-5-(1,2,3,4-tetrahydroxybutyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (1) with substituted -bromoacetophenones or -chloroacetophenone. Nearly all of the title compounds possess plant growth-promoting activities.…”