Synthesis and Biological Evaluation of Some Novel S-β-D-Glucosides of 4-Amino-5-alkyl-1,2,4-triazole-3-thiones Derivatives

Abstract

A novel series of 3-S-β-D-glucosides-4-arylideneamino-5-alkyl-1,2,4-triazoles were designed and synthesized by reaction of 4-amino-5-alkyl-4H-1,2,4triazole-3-thiol Schiff bases and 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide. The structures of the target compounds have been characterized by 1 H NMR, 13 C NMR, FT-IR, and Microanalyses. All the newly synthesized compounds have been screened for their in vitro antibacterial and antifungal activities against two Gram-positive bacteria [Bacillus cereus (PTCC 1015) and Staphylococcus aureus (ATCC 25923)], two Gram-negative bacteria [Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (PTCC 1399) and two fungi [Aspergillus niger (PTCC 5012) and Candida albicans (PTCC 5027)].

Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles

“…18 Furthermore, they exhibit large variety of medical activities. 19 Triazole glycosides are also present in the structures of various antiviral drugs such as Ribavirin and β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. 20 Isoxazole derivatives are pertinent class of bioactive Srinivas and Rao: Synthesis and Anticancer Activity ... molecules, which express glaring activities such as protein tyrosinephosphatase 1 inhibitors, 21 antiviral, 22 antihelmintic, 23 antiinflammatory, 24 anticonvulsant, 25 insecticidal, 26 antitubercular, 27 immunomodulatory, 28 and hypolipermic.…”