Synthesis and biological evaluation of carbohydrate appended hydrazinocyclopentenes with potent glycation and α-glucosidase inhibition activities

Ajish, K.R.; Joseph, Nayana; Rani, Mubeen; Raghu, K.; Vineetha, Vadavanath Prabhakaran; Radhakrishnan, K. V.

doi:10.1016/j.tetlet.2013.08.022

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…[10] In addition, acetylation of another hydroxy group decreasest he inhibitory activity. However, it exhibits poor inhibitory activity to a-amylase.…”

Section: A-glucosidase Inhibitorsmentioning

confidence: 99%

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Recent Advances in Synthetic α‐Glucosidase Inhibitors

Liu

2017

ChemMedChem

108

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Over the past few years, the number of people diagnosed with type 2 diabetes has increased owing to an unhealthy diet, a limited amount of exercise, and obesity. The search for novel and efficient antidiabetes agents has become an urgent task for scientists. Among the antidiabetes drugs, α-glucosidase inhibitor drugs have been proven to have many advantages over other drugs, and therefore, a large number of new compounds as α-glucosidase inhibitors has recently been reported. In this review, we summarize these newly found α-glucosidase inhibitors and their structure-activity relationships in antidiabetic studies and provide better structures for α-glucosidase inhibitors or even preclinical candidates. Beyond that, some enlightening strategies for the synthesis of relevant compounds are highlighted.

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“…[10] In addition, acetylation of another hydroxy group decreasest he inhibitory activity. However, it exhibits poor inhibitory activity to a-amylase.…”

Section: A-glucosidase Inhibitorsmentioning

confidence: 99%

“…However, it exhibits poor inhibitory activity to a-amylase. [10] In addition, acetylation of another hydroxy group decreasest he inhibitory activity.…”

Section: Monosaccharide Derivativesmentioning

confidence: 99%

Recent Advances in Synthetic α‐Glucosidase Inhibitors

Liu

2017

ChemMedChem

108

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“…13 However, this class has seen increased attention in the recent years with active research on isolation and screening of both natural and synthetic lead compounds. [14][15][16][17] AGIs are a class of compounds that inhibit the α-glucosidase enzyme ( Fig.7) located in the brush border cells of the small intestine. α-glucosidases are a class of enzymes that catalyze the final step in the digestion of carbohydrates.…”

Section: α-Glucosidase Inhibitors (Agis)mentioning

confidence: 99%

Development of phenylpropanoid sucrose esters (PSEs) as lead drug candidates for alpha glucosidase inhibition

Devaraj¹

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ChemInform Abstract: Synthesis and Biological Evaluation of Carbohydrate Appended Hydrazinocyclopentenes with Potent Glycation and α‐Glucosidase Inhibition Activities.

et al. 2014

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Synthesis and Biological Evaluation of Carbohydrate Appended Hydrazinocyclopentenes with Potent Glycation and α-Glucosidase Inhibition Activities. -Synthesis and biological evaluation of novel alkylidenecyclopentene glycohybrids like (IV) are described. Selected substances are screened against α-glucosidase, α-amylase, and glycation reactions. The results show that compound (IVb) acts as potent α-glucosidase inhibitor and anti-glycation agent under in vitro conditions. -(AJISH, K. R.; JOSEPH, N.; RANI, M. P.; RAGHU, K. G.; VINEETHA, V. P.; RADHAKRISHNAN*, K. V.; Tetrahedron Lett. 54 (2013) 42, 5682-5685, http://dx.

show abstract

Synthesis and biological evaluation of carbohydrate appended hydrazinocyclopentenes with potent glycation and α-glucosidase inhibition activities

Cited by 8 publications

References 47 publications

Recent Advances in Synthetic α‐Glucosidase Inhibitors

Recent Advances in Synthetic α‐Glucosidase Inhibitors

Development of phenylpropanoid sucrose esters (PSEs) as lead drug candidates for alpha glucosidase inhibition

ChemInform Abstract: Synthesis and Biological Evaluation of Carbohydrate Appended Hydrazinocyclopentenes with Potent Glycation and α‐Glucosidase Inhibition Activities.

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