Synthesis and biological and physico-chemical characterization of glycodendrimers and oligopeptides for the treatment of systemic lupus erythematosus

Tassinari, Sarah; Moreno, Sílvia; Komber, Hartmut; Carloni, Riccardo; Cangiotti, Michela; Ottaviani, M. Francesca; Appelhans, Dietmar

doi:10.1039/d1nr06583a

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…After grafting with MTX, the zeta potential of the dendrimer changed a little and still carries massive positive charges, and due to electrostatic interactions, the cationic polymers can remove negatively charged inflammatory cytokines and cellular debris to impede the progression of arthritic inflammation in the RA model (Figure 2c). [39][40][41][42] To mimic the cellular hierarchical structure, the formulated G-MTX was loaded into hydrogel microspheres (H-G-MTX) using microfluidics. HAMA was an ideal material for the preparation of hydrogel microspheres because of its unique biocompatibility and its ability to lubricate joints.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment

Li,

Zhu,

Liu

et al. 2023

Small Science

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Rheumatoid arthritis (RA) is one of the leading causes of disability due to the autoimmune destruction of synovial joints. Great efforts have been put into developing multifunctional drug delivery systems for delaying the progression of RA. Herein, a novel locally injectable, hierarchically structured delivery system with a hyaluronic acid (HA) microparticle and an MTX‐conjugated nanoparticle for promoted RA treatment is proposed. In this system, MTX is chemically grafted onto a peptide dendrimer‐based nanoparticle (G‐MTX). These nanoparticles are encapsulated inside HA microparticles (H‐G‐MTX) using microfluidics to realize the system. The G‐MTX can be released from the degradable HA microparticles in the acidic environment of inflamed RA joints. As the G‐MTX shows an enhanced intracellular delivery of the conjugated MTX, the H‐G‐MTX can reverse the dominant macrophage phenotype from M1 to M2. Through a collagen‐induced arthritis (CIA) rat model, the great therapeutic outcomes of this hierarchically structured delivery system are demonstrated, including inflammation reduction, cartilage protection, and bone mineral density promotion. These results indicate that the proposed hierarchical delivery system has potential clinical value in the treatment of RA and other diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment

Li,

Zhu,

Liu

et al. 2023

Small Science

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“…To address the pathological manifestations associated with SLE, it is crucial to disrupt or inhibit the formation of these immunocomplexes. In a German, Italian and American effort, different generations of maltose-decorated PAMAM and PPI dendrimers, along with two oligopeptides containing polyethylene glycol units, were synthesized, characterized, and evaluated for their anti-SLE activity [ 94 ]. The activity of glycodendrimers and oligopeptides was evaluated using enzyme-linked immunosorbent assay (ELISA) and EPR techniques in human plasma samples from SLE patients and healthy individuals.…”

Section: Covalent Dendrimers Self-assembling Dendrimers and Dendrimer...mentioning

confidence: 99%

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic

Pricl

2023

Pharmaceutics

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COST Action CA17140 Cancer Nanomedicine—from the bench to the bedside (Nano2Clinic,) is the first, pan-European interdisciplinary network of representatives from academic institutions and small and medium enterprises including clinical research organizations (CROs) devoted to the development of nanosystems carrying anticancer drugs from their initial design, preclinical testing of efficacy, pharmacokinetics and toxicity to the preparation of detailed protocols needed for the first phase of their clinical studies. By promoting scientific exchanges, technological implementation, and innovative solutions, the action aims at providing a timely instrument to rationalize and focus research efforts at the European level in dealing with the grand challenge of nanomedicine translation in cancer, one of the major and societal-burdening human pathologies. Within CA17140, dendrimers in all their forms (from covalent to self-assembling dendrons) play a vital role as powerful nanotheranostic agents in oncology; therefore, the purpose of this review work is to gather and summarize the major results in the field stemming from collaborative efforts in the framework of the European Nano2Clinic COST Action.

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Cationic nanoparticles-based approaches for immune tolerance induction in vivo

Mao,

Wang,

Xie

et al. 2024

Journal of Controlled Release

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Synthesis and biological and physico-chemical characterization of glycodendrimers and oligopeptides for the treatment of systemic lupus erythematosus

Abstract: Anti-(ds)-DNA antibodies are the serological hallmark of Systemic Lupus Erythematosus (SLE). They assemble in the bloodstream with the (ds)-DNA, forming immunocomplexes, which spread all over the body causing, among the...

Cited by 4 publications

References 39 publications

Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment

Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic

Cationic nanoparticles-based approaches for immune tolerance induction in vivo

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