Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment
Yang Li,
Haofang Zhu,
Rui Liu
et al.
Abstract:Rheumatoid arthritis (RA) is one of the leading causes of disability due to the autoimmune destruction of synovial joints. Great efforts have been put into developing multifunctional drug delivery systems for delaying the progression of RA. Herein, a novel locally injectable, hierarchically structured delivery system with a hyaluronic acid (HA) microparticle and an MTX‐conjugated nanoparticle for promoted RA treatment is proposed. In this system, MTX is chemically grafted onto a peptide dendrimer‐based nanopar… Show more
Rheumatoid arthritis (RA) is a progressive autoimmune disease mainly affecting the inner lining of the synovial joints and leading to chronic inflammation. While RA is not known as lethal, recent...
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