Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups

Eropkin, M. Yu.; Melenevskaya, E. Yu.; Nasonova, K. V.; Bryazzhikova, T. S.; Еропкина, Е. М.; Danilenko, Daria; Киселев, О. И.

doi:10.1007/s11094-013-0901-x

Cited by 33 publications

(41 citation statements)

References 13 publications

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“…Toxicity of water solutions of model oxidizers K 3 [Fe(CN) 6 ] (potassium ferricyanide) and 1,4-benzoquinone was assessed using enzymatic assay, that is the preparation based on the coupled enzyme system NADH:FMN-oxidoreductase from Vibrio fischeri (0.15 a.u.) and luciferase from Photobacterium leiognathi, 0.5 mg mL À1 (35).…”

Section: Methodsmentioning

confidence: 99%

“…Being bioactive compounds, fullerenols can produce either toxic or activating effect (3)(4)(5)(6). The biological activity of a series of fullerenols C 60 (OH) [12][13][14] , C 60 (OH) [18][19][20][21][22][23][24] , C 60 (OH) [30][31][32][33][34][35][36][37][38] was studied by Eropkin and coworkers (3).…”

Section: Introductionmentioning

confidence: 99%

“…The biological activity of a series of fullerenols C 60 (OH) [12][13][14] , C 60 (OH) [18][19][20][21][22][23][24] , C 60 (OH) [30][31][32][33][34][35][36][37][38] was studied by Eropkin and coworkers (3). Fullerenols C 60 (OH) [18][19][20][21][22][23][24] have revealed maximal biological activity (4,7,8).…”

Section: Introductionmentioning

confidence: 99%

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Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds

Kudryasheva

Kovel

Sachkova

et al. 2016

Photochem & Photobiology

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A bioluminescent assay based on a system of coupled enzymatic reactions catalyzed by bacterial luciferase and NADH: FMN-oxidoreductase was developed to monitor toxicity and antioxidant activity of bioactive compounds. The assay enables studying toxic effects at the level of biomolecules and physicochemical processes, as well as determining the toxicity of general and oxidative types. Toxic and detoxifying effects of bioactive compounds were studied. Fullerenols, perspective pharmaceutical agents, nanosized particles, water-soluble polyhydroxylated fullerene-60 derivatives were chosen as bioactive compounds. Two homologous fullerenols with different number and type of substituents, C 60 O 2-4 (OH) [20][21][22][23][24] and Fe 0.5 C 60 (OH) x O y (x + y = 40-42), were used. They suppressed bioluminescent intensity at concentrations >0.01 g L À1 and >0.001 g L À1 for C 60 O 2-4 (OH) 20-24 and Fe 0.5 C 60 (OH) x O y , respectively; hence, a lower toxicity of C 60 O 2-4 (OH) 20-24 was demonstrated. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic oxidizers; changes in toxicities of general and oxidative type were determined; detoxification coefficients were calculated. Fullerenol C 60 O 2-4 (OH) 20-24 revealed higher antioxidant ability at concentrations 10 À17 À10 À5 g L À1 . The difference in the toxicity and antioxidant activity of fullerenols was explained through their electron donor/acceptor properties and different catalytic activity. Principles of bioluminescent enzyme assay application for evaluating the toxic effect and antioxidant activity of bioactive compounds were summarized.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds

Kudryasheva

Kovel

Sachkova

et al. 2016

Photochem & Photobiology

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“…11). A number of papers have reported that C 60 (OH) 10 has a low biological activity and toxicity in biological media [9,15]. The above findings show that C 60 (OH) 10 acquired a high ability for scavenging ROS and exerted a protective effect against liver injury by virtue of the formation of water soluble nanoparticles.…”

Section: Discussionmentioning

confidence: 80%

“…Polyhydroxylated fullerenes (fullerenol, C 60 (OH) n ), some of the simplest C 60 derivatives, show improved solubility in aqueous media. The number of hydroxyl groups introduced into a C 60 molecule is a key factor for enhancing the hydrophilicity of the material as well as its biological activity [9,10]. Fullerenols are regarded as potential candidates for use in scavenging reactive oxygen species (ROS), which arise due to neuroprotective [11] and cytoprotective [12] effects by reducing oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen

et al. 2015

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Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Babu

Pawar

Mittal

et al. 2023

WIREs Nanomed Nanobiotechnol

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Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer‐term exposure to adverse environmental conditions. Among these challenges, radiation‐induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro‐gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio‐absorption cross‐section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon‐based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation‐induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups

Cited by 33 publications

References 13 publications

Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds

Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds

Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

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