Synthesis and biological activity of 2‐substituted‐3‐ethyl‐N‐alkyl/arylindoles

Abstract

Some new 2‐substituted‐N‐(aminomethylaryl/aminoethylaryl)indole‐3ylglyoxylamides 3a‐h and their corresponding 2‐substituted‐3‐ethyl‐N‐alkyl/aryl indoles 4a‐d,f,g were synthesized. These compounds were evaluated for their cardiovascular as well as antiparkinsonian activities.

A facile one-pot synthesis of novel 1-substituted 2-(8-hydroxyquinolin-5-yl)-1,5,6,7-tetrahydro-6,6-dimethyl- 4H-indol-4-one derivatives

“…[1][2][3][4] It is found in the recent literature that several indole derivatives are reported to possess a wide variety of biological properties, e.g. CNS depressant, 5 anti-inflammatory and analgesic, 6 antiviral, 7 anthelmintic, 8 antibacterial, 9 anticonvulsant, 10 cardiovascular, 11 and antihypertensive activity. 12 In recent years, 1,4-diazabicyclo[2.2.2]octane (DABCO) has emerged as a promoter for various organic reactions.…”