Synthesis and biological activity of amides of 28-methoxy-28-oxo-1-cyano-2,3-seco-lup-20(29)-en-3-oic acid

N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide

“…Amides bearing a trifluoromethyl substituent show a broad spectrum of pharmacological properties, including antitumour [1], anti-inflammatory [2], antioxidant [3], analgesic [4] and antiviral activity [5]. It was also reported that substituted amides show higher anticonvulsive [6], hypoglycemic [7], antiarrhythmic [8] and fungicidal activity [9].…”