N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized by reacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis
The title compound, C7H7ClN2O, crystallizes with two independent molecules in the asymmetric unit. The compound adopts an E configuration across the C=N double bond, as the –OH group and the benzene ring are on opposite sides of the double bond while the H atom of the hydroxy group is directed away from the –NH2 group. In the crystal, molecules are linked to one another through O—H⋯N and N—H⋯O hydrogen bonds, forming chains along [010].
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