Synthesis and biological activity of new functionalised cyclohepta[4,5]-thieno[2,3-d][1,2,4] triazolo[4,3-a]pyrimidin-5-ones

Abstract

Various functionalised derivatives of 5H-cyclohepta [4,5]thieno [2,3-d][1,2,4]triazolo [4,3-a]pyrimidin-5-one were synthesised via reaction of hydrazonoyl halides (1) with either 1,2,3,5,6,7,8,9-octahydro-2-thioxo-4H-cyclohepta- [4,5]thieno [2,3-d]pyrimidin-4-one (2) or its methylthio derivative (3). The mechanism and the regioselectivity of the studied reactions are investigated and discussed.

A Convenient One‐Pot Synthesis of Thieno[2′,3′:4,5]Pyrimido[1,2‐b]‐[1,2,4,5]Tetrazines

“…On the other hand, some thieno[2,3:4,5]pyrimido[1,2‐ b ][1,2,4,5]tetrazines have been reported for different biological activities such as antimicrobial, anti‐inflammatory, and analgesic activities . In view of the earlier observations and in continuation of our interest in the chemistry of thieno[2,3‐d]pyrimidines and hydrazonoyl halides , we report herein direct, efficient, and regioselective synthesis of thieno[2′,3′:4,5]pyrimido[1,2‐ b ][1,2,4,5]tetrazin‐6‐one derivatives in order to find new pharmacological or biologically active compounds.…”

“…The derivatives of pyrimidine are well known as compounds with a high level of biological activities. In particular, thieno[2,3‐ d ]pyrimidine derivatives have attracted a great deal of interest owing to their biological and pharmacological properties . Some tetrazine derivatives were identified to be one of the most potent inhibitors of the human cytomegalovirus protease .…”

Synthesis of Some New S-Nucleoside Derivatives of 2-Thioxo and (2,4-Dithioxo)-5,6,7,8-Tetrahydrobenzo-Thieno[2,3-d]Pyrimidin-4-(3H)Ones

“…4,5 Other differently substituted thieno[2, 3-d]pyrimidine nucleosides as antiviral agents against hepatitis-A virus (HAV) have been recently described. 6 In light of these considerations and in continuation of the studies in the chemistry of nucleosides and thieno[2, 3-d]pyrimidine, [7][8][9][10][11][12][22][23][24] we thought it interesting to investigate the synthesis of some new nucleosides of thieno[2, 3-d]pyrimidine.…”