Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one

Abstract

A small series of pyrazoles and isoxazoles derived from thiochroman-4-one has been synthesized and characterized. The compounds were examined for their in vitro inhibitory activity against Bacillus subtilis and Pseudomonas fluorescens. Among the tested compounds the pyrazole derivative from thiochroman-4-one was found to be the most effective inhibitor of growth of B. subtilis. Extensive H NMR analysis was recorded for all compounds.

Fused heterocycles 11.1 Synthesis of tricyclic fused pyrazolines by the reaction of 3-arylidenechromanones and 3-arylidene-1-thiochromanones with hydrazine

“…Owing to their useful bioactivities, [2][3][4] increasing attention has been focused on this ring system. 2-Pyrazolines seem to be the most frequently studied pyrazoline type compounds.…”

Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines

“…Pyrazolines are also used as optical brighteners and whiteners. They display various biological activities such as antimicrobial [2], antifungal [3], antidepressant [4], immunosuppressive [5], anticonvulsant [6], anti-tumor [7], antiamoebic [8], antibacterial [9] and antiinflammatory [10] activities. Synthesis of pyrazolines by reaction of α,β-unsaturated carbonyl compounds with diazoalkanes [11] or with hydrazine hydrate were reported in the literature [12,13].…”

Synthesis of carboxylic acid derivatives of 2-pyrazolines

“…[1][2][3] Numerous pyrazolines have been found to possess important bioactivities, viz. central nervous system, 4 antimicrobial and antimycotic, 5,6 immunosuppressive, 7 etc. activities.…”