Synthesis and characterization of 1-formyl-3-phenyl-5-aryl-2-pyrazolines

Synthesis of pyrazoline derivatives from the 1,3-dipolar cycloadditions using α,β-unsaturated cyclohexanone derivatives

“…When the reaction was repeated using ethanol as solvent rather glacial acetic acid, compound 3a was obtained in high yield (92%) (Scheme 2). Pyrazolines 3b and 3d were obtained by reaction of compounds 2b and 2c respectively with hydrazine hydrate in ethanol using the same procedure given for compound 3a [43]. …”

Acetylenes in the Superbase-Promoted Assembly of Carbocycles and Heterocycles

“…Pyrazole structures have been incorporated into a variety of drugs, and pyrazoles themselves represent medicinally important building blocks . Literature reports on the synthesis of 1-formyl-4,5-dihydropyrazoles are sporadic; however, some of these species exhibit antitumor, antibacterial, and antimicrobial activity.…”

Synthesis and antifungal activity of novel pyrazolines and isoxazolines derived from cuminaldehyde

“…Preparation of β-unsaturated chalcones (1a-1l) In this study, α,β-unsaturated chalcones 1 were synthesized by using a Claisen-Schmidt reaction. 9,[14][15][16] To a solution of substi-tuted acetophenone (20 mmol) and cuminaldehyde (20 mmol) in 15 mL of ethanol, 0.5 mL of 1 mol•L −1 NaOH solution was added drop by drop. The mixture was stirred overnight at room temperature, and then the solvent was removed under reduced pressure.…”