Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists

Experimental and computational thermochemistry of 1-phenylpyrrole and 1-(4-methylphenyl)pyrrole

“…The phenylpyrrole derivatives show important therapeutic applications, biological activity and have interesting pharmacological properties [5][6][7]. They possess antispasmodic [8], antiviral [9], and antioxidant activities [10], which may be useful in the treatment of pathologies where free radical oxidation plays a fundamental role.…”

In Vitro Evaluation of Selected Benzimidazole Derivatives as an Antioxidant and Xanthine Oxidase Inhibitors

“…Benzimidazoles and their derivatives constitute an important class of compounds in organic chemistry attributing to their enormous application in biological field. Several benzimidazole derivatives have been reported to exhibit biological activities viz anticancer , antihypertensive , antiviral , vasodilator , and antimicrobial . These compounds have also been reported to act as antitumor , anthlemintic and antihistaminic , anti‐ HIV , and selective neuropeptide YY1 receptor antagonists , 5‐lipo‐oxygenase inhibitors for use as novel anti‐allergic agents ; factor Xa (FXa) inhibitors .…”

A V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl) benzylamine with its cobalt(II) complex: synthesis, crystal structure, DNA-binding properties, and antioxidant activity

“…Benzimidazole and its derivatives have attracted interest because of their varied biological activities namely anticancer [9], antihypertensive [10], antiviral [11], anti-inflammatory [12], vasodilator [13], and antimicrobial [14][15][16]. Moreover, as a typical heterocyclic ligand, large benzimidazole rings can not only provide potential supramolecular recognition sites for Á Á Á stacking interactions, but can also act as hydrogen-bond acceptors and donors to assemble multiple coordination geometries [17].…”