A V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl) benzylamine with its cobalt(II) complex: synthesis, crystal structure, DNA-binding properties, and antioxidant activity

Abstract

A V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl)benzylamine (bmbb) and its cobalt complex, [Co(bmbb) 2 ](pic) 2 (pic ¼ picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single-crystal X-ray revealed that the coordination sphere around Co(II) is distorted octahedral with an N 6 ligand set from two tridentate bmbb. The DNA-binding properties of bmbb and the Co(II) complex were investigated by spectrophotometric and viscosity measurements. The results suggest that bmbb and Co(II) complex both bind to DNA via intercalation, and the Co(II) complex binds to DNA more strongly than bmbb. The Co(II) complex also exhibited potential antioxidant properties in vitro studies.

Crystal structure of tris{(3-((E)-(((E)-2-oxidobenzylidene)hydrazono)methyl)-2-oxo-2H-chromen-4-olato-κ3 O,N:N′)}dicobalt(III)tris(dimethylformamide), C60H50Co2N9O15

“…In consideration of Schiff base and its derivatives, it can act as chelating ligand to form all kinds of stable transition metal complexes [16][17][18]. The Schiff bases Co(II,III) complexes exhibit a wide range of activities and applications, such as biochemistry [19], magnetic properties [20], photophysical properties [21] and so on. X-ray crystallographic analysis of the title compound reveals an asymmetric binuclear structure, which consists of two Co(III) ions, three L 2− ligands, and three noncoordinated N,N-dimethylformamide (DMF) molecules.…”