Synthesis and Biological Activity of Novel Phosphonate Derivatives Containing of Pyridyl and 1,2,3-Triazole Rings

Chen, Xiaobao; Shi, De‐Qing

doi:10.1080/10426500701578522

Cited by 26 publications

(18 citation statements)

References 12 publications

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“…[9] The derivatives obtained by different transformations of a-hydroxyphosphonates may also include biologically active species. [10][11][12][13] O-phosphorylation, nucleophilic substitution and catalytic debenzylation of a-hydroxyphosphonates result in valuable derivatives. Among those, a-aminophosphonates are of special importance due to their analogy to a-amino acid derivatives.…”

Section: Introductionmentioning

confidence: 99%

Green syntheses of potentially bioactive α-hydroxyphosphonates and related derivatives

Kiss

Rádai

Keglevich

2019

Phosphorus, Sulfur, and Silicon and the Related Elements

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a-Hydroxyphosphonates have been in the focus of interest for many years due to their potential in biological activity. Not only a-hydroxyphosphonates are of general importance, but also their derivatives. a-Aminophosphonates and a-hydroxyphosphonic acids have already been recognized for their biological effects, while phosphoryloxyphosphonates represent a new family of compounds. In this paper we present alternative syntheses towards a-hydroxyphosphonates and their derivatives.

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Section: Introductionmentioning

confidence: 99%

Green syntheses of potentially bioactive α-hydroxyphosphonates and related derivatives

Kiss

Rádai

Keglevich

2019

Phosphorus, Sulfur, and Silicon and the Related Elements

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“…On the other hand, pyridine is a significant nitrogen‐containing heterocyclic compound, and its derivatives also show a wide spectrum of biological properties, including antifungal, antimicrobial, antitumor, antiviral, herbicidal, and insecticidal activities. Many pyridine derivatives play crucial roles as agrochemicals due to their high activity, low toxicity, and excellent selectivity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antifungal Activity Evaluation of Novel Substituted Pyrimidine‐5‐Carboxamides Bearing the Pyridine Moiety

Wang

Wan

Liu

et al. 2018

J Chinese Chemical Soc

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A series of novel N‐(substituted phenyl/benzyl)‐2‐methylthio‐4‐((pyridin‐3‐ylmethyl)amino)pyrimidine‐5‐carboxamides were synthesized by multistep reactions. The structures of the target compounds were characterized by IR, 1H NMR, 13C NMR, and elemental analysis. Their in vitro antifungal activities against two kinds of plant pathogenic fungi were evaluated by the mycelial growth rate method. The result showed that at the dosage of 100 μg/mL, several of these compounds exhibited moderate activity against Botrytis cinerea with inhibition rates of ~70%, and most compounds (e.g., 5a, 5c, 5e, 5f, and 5h) possessed excellent activity against Sclerotinia Sclerotiorum with more than 90% inhibition rate.

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“…Moreover, organophosphorus has received much attention due to their broad spectrum of biological activities such as antimicrobial, cytotoxic, and antiviral agents . Many of the numerous types of heterocyclic compounds containing phosphorus displayed significant insecticidal, herbicidal, and antifungal properties . Furthermore, it has been reported that many biologically active natural and synthetic products have interesting molecular symmetry .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of New Bis‐1,3,4,2‐triazaphospholinoalkane Derivatives as In Vitro α‐Amylase and Lipase Inhibitors

Hamzaoui

Salah

Hamden

et al. 2015

Archiv der Pharmazie

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A series of new 1,ω-bis-(5-alkyl-2-oxide-3-tosyl-1,3,4,2-triazaphospholino)alkanes 2 and 3 were prepared in good yields by the treatment of 1,ω-bis-(1-tosylamidrazone)alkanes 1 with two molar equivalents of phosphoryl trichloride and phenylphosphonic dichloride, respectively. All the newly synthesized compounds were characterized by IR, (1) H NMR, (13) C NMR, (31) P NMR, and elemental analysis. All the new compounds were screened for their inhibitory effect on the key enzymes related to diabetes and obesity, as α-amylase and lipase. The in vitro study revealed that these alkane derivatives exert an inhibitory action against these key enzymes, especially 2b with an IC50 of 16 μg/mL against α-amylase and lipase. Overall, the findings of the current study indicate that 2d exhibits attractive properties and can therefore be considered for future application in the development of antidiabetic and hypolipidemic drugs.

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Synthesis and Biological Activity of Novel Phosphonate Derivatives Containing of Pyridyl and 1,2,3-Triazole Rings

Cited by 26 publications

References 12 publications

Green syntheses of potentially bioactive α-hydroxyphosphonates and related derivatives

Green syntheses of potentially bioactive α-hydroxyphosphonates and related derivatives

Synthesis and Antifungal Activity Evaluation of Novel Substituted Pyrimidine‐5‐Carboxamides Bearing the Pyridine Moiety

Synthesis and Evaluation of New Bis‐1,3,4,2‐triazaphospholinoalkane Derivatives as In Vitro α‐Amylase and Lipase Inhibitors

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