Synthesis and biological activity of synthetic 17α-hydroxyprogesterone derivatives

Zeinalov, O. A.; Yaderets, V. V.; Stytsenko, T. S.; Petrosyan, M. A.; Andryushina, V. A.

doi:10.1007/s11094-012-0761-9

Cited by 4 publications

(3 citation statements)

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“…47 However, a case report involving a prepubertal 7-month-old Maine Coon queen weighing 4.2 kg that developed benign mammary hyperplasia 4 weeks after being treated with a fairly low dose of 0.75 ml (17.8 mg/kg) PRG cautions that perhaps the mammary gland remains an important target for the action of PRG. 48 in female rabbits, PRG causes a significantly lower degree of endometrial proliferation compared with both MA and exogenous progesterone, 49 although it is unknown whether a lower uterine effect likewise occurs in queens. Similar to other progestogens, PRG can also cause calcinosis circumscripta (local deposition of calcium salts presenting as nodules, often at an SC injection site) in cats.…”

Section: Medroxyprogesterone Acetatementioning

confidence: 99%

Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity

Romagnoli

Ferré-Dolcet²

2022

Journal of Feline Medicine and Surgery

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Background: The literature is full of papers reporting side effects of progestogens in cats; however, they are, in fact, safe drugs, as discussed in this article. Gonadotropin-releasing hormone (GnRH) agonists and melatonin are additionally a practical solution for controlling cyclicity in queens, but they also have some contraindications and need to be used carefully. Clinical relevance: Mastering the use of reproductive drugs allows feline practitioners to handle many more clinical situations than can be solved using surgery. It is not necessary to be a specialist in reproduction to be able to halt cyclicity in a valuable breeding queen using hormones. Equipment and technical skills: A sound knowledge of appropriate dosages and criteria for patient selection for all reproductive drugs currently used in feline reproduction is the best guarantee of owner satisfaction and of ensuring the queen’s health. Availability of a serum progesterone assay, either in-house or via an external laboratory, is also important, in order to confirm a queen is at an appropriate stage of the reproductive cycle for treatment. Audience: This article is aimed principally (but not exclusively) at veterinarians working with cat breeders and whose clientele is increasingly interested in alternative methods of controlling reproduction in pet queens. Surgery is no longer the only choice, and practitioners who manage to keep abreast of new developments will be able to address clients’ needs in a modern, professional way. Evidence base: This review draws on a vast body of scientific evidence-based literature. Previously, personal (and sometimes misinformed) opinions, such as the proposed dangerous side effects of progestogens, have been perpetuated in the scientific literature. The papers cited in this review have therefore been carefully scrutinised to distinguish reliable information based on controlled studies from non-evidence-based information.

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Section: Medroxyprogesterone Acetatementioning

confidence: 99%

Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity

Romagnoli

Ferré-Dolcet²

2022

Journal of Feline Medicine and Surgery

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“…In the Russian Federation over the past few years the number of small domestic animals with reproductive pathology has increased significantly and ranges from 10-20%. [8,9,13]. It is known that the polycyclicity of cats increases the risk of developing reproductive pathologies in comparison with dogs.…”

Section: Introductionmentioning

confidence: 99%

“…To eliminate the behavioral manifestations associated with the sexual heat of cats, which is extremely important for those who have cats at homes, the most widely used methods have been the delay or prevention of estrus with the help of hormonal gestogen-containing drugs. [1,8,9,10] Therefore, studies of pedigree and age predispositions to reproductive disorders in cats remain relevant and will make it possible to timely detect the causes and development of disease in latent flow and subsequently apply modern methods of diagnosis, treatment and prevention of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Reproductive Disorders of Cats and Means Used to Correct Them

Столбова¹,

Скосырских²,

Kruglov³

2018

International Scientific and Practical Conference "AgroSMART - Smart Solutions for Agriculture" (AgroSMART 2018)

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The research work was carried out in the period from 2014 to 2018 in the city of Tyumen. In this period 3.237 cats of different breeds and ages were examined. The investigated reproductive disorders were found in 389 cats. It was established that these disorders are widespread in Tyumen and their percentage ranges from 12.02 to ± 0.195Purulent endometritis was most often observed in the following breeds: Mestizo -32.89% of cases, Scottish fold -25.00%, British shorthair -14.47%, Abyssinian -7.89%. Cystic ovarian formations were recorded in Mestizos -46.56%, British short-haired -21.37%, Scottish folds -18.32%, Sphynxes -7.63%. Tumors of mammary glands were found in cats of such breeds as Mestizo -40.00%, Sphinx -23.63%, Persian -14.54%, Siamese -14.50%, Abyssinian -7.27%. The predisposition of cats to purulent endometritis has increased in the following age groups: 11.84% from 4 to 5 years old, 11.84% from 5 to 6 years old, and 10.52% from 7 to 8 years old. 11.45% of cats from 2 to 3 years old had predisposition to the ovarian cysts: 10.68% of cats were at the age ranging from 3 to 4 years old; 11.45% were from 4 to 5 years old; 11.45% were cats from 5 to 6 years and 12.21% from 6 to 7 years old. Tumors of mammary glands were registered more often in the age groups from 8 to 9 years old and amounted to 12.72%; from 9 to 10 years old this number comprised 12.72%; and over 10 years old it was 18.18%. To treat diseases or disorders of the reproductive system organs of cats, the gestagenic drugs produced either in Russia or abroad are used. In the Russian pharmaceutical market there are 33 gestagenic drugs. The share of domestic producers is 91%, which is equal to 92 items and the share of foreign producers is 9%, which is 9 items.

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Synthesis and Cytostatic Activity of New Mepregenol 17-Acetate Derivatives with Respect to Hela Cancer Cell Culture

et al. 2020

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Synthesis and biological activity of synthetic 17α-hydroxyprogesterone derivatives

Cited by 4 publications

References 0 publications

Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity

Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity

Analysis of Reproductive Disorders of Cats and Means Used to Correct Them

Synthesis and Cytostatic Activity of New Mepregenol 17-Acetate Derivatives with Respect to Hela Cancer Cell Culture

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