Synthesis and Biological Activity of Some Novel Derivatives of
4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid

Pothuri, Vijai Varma; Machiraju, P.V.S.; Rao, V. Samba Siva

doi:10.1134/s1070363220050229

Cited by 5 publications

(1 citation statement)

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“…Many biologically active products contain derivatives of these heterocyclic compounds [ 1 , 2 , 3 ]. Derivatives containing isoxazole/isoxazoline fragments possess biological activities such as anticancer [ 4 , 5 ], anti-inflammatory [ 6 , 7 ], antibacterial [ 8 , 9 ], anti-Alzheimer’s disease [ 10 , 11 ], antioxidant [ 12 , 13 ], insecticidal [ 14 ], antifungal [ 15 , 16 ], and antidiabetic [ 17 , 18 ]. Isoxazolines and isoxazoles have unique electron-rich aromatic structures and have received much attention [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Wang

Tang

et al. 2023

Pharmaceuticals

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Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.

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Section: Introductionmentioning

confidence: 99%

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Wang

Tang

et al. 2023

Pharmaceuticals

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Synthesis of 3‐Acyl‐Isoxazoles via Radical 5‐endo trig Cyclization of β,γ‐Unsaturated Ketones with NaNO₂

et al. 2022

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Here we report a facile cyclization reaction of β,γ-unsaturated ketones with NaNO 2 under mild conditions to construct 3-acylisoxazoles. This transformation is realized via nitrosation of the activated methylene, radical 5-endo trig cyclization, and then aromatization, according to some control experiments. Further, this protocol provided an efficient access to a variety of isoxazoles from readily available allyl ketones.

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A review of recent synthetic strategies and biological activities of isoxazole

Pandhurnekar¹,

Pandhurnekar

Mungole³

et al. 2022

Journal of Heterocyclic Chem

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Among different heterocyclic compounds, isoxazole and their analogues are very important classes of heterocyclic compounds as they display an extensive range of biological actions. This makes such scaffolds very important structures in the field of medicinal chemistry. From an extensive literature assessment, isoxazole is clinically proven to be very effective as an anti‐bacterial, anti‐fungal, anti‐inflammatory, anti‐cancer, anti‐tubercular, and anti‐neoplastic agent. The different derivatives of isoxazole which exhibits adjustment in their structure have shown a high degree of variety in their medicinal properties which makes evident them as very beneficial in the progress of novel bioactive drugs which show enhanced effectiveness along with minor harmfulness. Structural aspects of isoxazole having aromaticity with weaker nitrogen‐oxygen bonding provide a potential site for the ring cleavage. Thus, this isoxazole ring system allows easier modifications of substituents in their ring structure which consequently make isoxazole very useful intermediates in various synthetic routes of bioactive compounds. Hence, the synthesis and evaluation of isoxazole‐containing molecules with wider therapeutic consequences are always the topic of interest for chemists. Hence, in light of this comprehensive research on isoxazole, it is thought worthwhile to review various pathways for the synthesis of isoxazole analogues and having a broad spectrum of bioactive actions.

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Synthesis and Biological Activity of Some Novel Derivatives of 4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid

Cited by 5 publications

References 5 publications

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Synthesis of 3‐Acyl‐Isoxazoles via Radical 5‐endo trig Cyclization of β,γ‐Unsaturated Ketones with NaNO₂

A review of recent synthetic strategies and biological activities of isoxazole

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Synthesis and Biological Activity of Some Novel Derivatives of 4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid

Cited by 5 publications

References 5 publications

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Synthesis of 3‐Acyl‐Isoxazoles via Radical 5‐endo trig Cyclization of β,γ‐Unsaturated Ketones with NaNO2

A review of recent synthetic strategies and biological activities of isoxazole

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Product

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Synthesis of 3‐Acyl‐Isoxazoles via Radical 5‐endo trig Cyclization of β,γ‐Unsaturated Ketones with NaNO₂