Synthesis and biological activities of new 1H-1,2,4-triazole derivatives containing ferrocenyl moiety

Synthesis of novel triazole derivatives as potent inhibitor of allene oxide synthase (CYP74A), a key enzyme in jasmonic acid biosynthesis

“…2a was prepared using phenacyl bromide as the starting material, as described previously. 17) To a vigorously stirred suspension of 1H-1,2,4-triazole (5.52 g, 0.08 mol) and phenacyl bromide 1a (9.95 g, 0.05 mol) in 30 mL acetone, was added triethylamine (8.1 g, 0.05 mol) drop-wise over a period of 1 hr with the temperature below 0°C, and the reaction mixture was stirred for another 30 min at room temperature. e mixture was ltered to remove triethylamine hydrobromide salt precipitates, the precipitates was washed with 3×10 mL acetone, the ltrate was evaporated under reduced pressure, and the residues were dissolved in 50 mL chloroform and then washed with 2×25 mL water.…”

Biheterocyclic ligands: synthesis, characterization and coordinating properties of bis(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes with transition metal ions and their thermokinetic and biological studies

“…Due to instrumental limitation, the values of ν 2 and ν 3 obtained from the electronic spectra are used to calculate the third transition, 4 T 1g → 4 T 2g (F) (ν 1 ) band by the equations used for the d 7 system [32] and found to be 6948 cm -1 . From these transition bands the ligands field parameters (Table 3) calculated for the Co(II) complex of BAT3 ligand are B = 889 cm -1 , β = 0.92, 10Dq = 7889 cm -1 and ν 2 /ν 1 = 2.14 , respectively.…”

“…The electronic spectrum of [Cu 2 (BAT3) (H 2 O) 4 Cl 4 ]·3/2H 2 O·1/4C 2 H 5 OH, show weak shoulders at 18,797 cm -1 and 13,736 cm -1 . These bands are due to 2 B 1g → 2 E g and 2 B 1g → 2 A 1g transitions in a distorted octahedral geometry [30,32].…”

“…In recent years, considerable attention has been paid to the synthesis of biheterocyclic compounds that play a significant role in many pharmacological, biological activities, therapeutic effect and plant growth [1][2][3][4][5][6][7]. Antimicrobial activities of some new biheterocyclic compounds were reported recently [5].…”

Quinolin-6-Amines: Synthesis and Biological Evaluation

“…The 1,2,4-triazole derivatives were allied with various pharmacological activities viz. antiseptic, analgesic, anti-convulsant [26][27][28][29][30][31][32][33][34][35][36][37], antibiotic [26], antiallergic [26], anti-inflammatory [26][27][28][29][30][31][32][33][34][35]38], diuretic [26,30,33], fungicidal [28][29][35][36][37][38], insecticidal [28,35,38], herbicidal [28,35,38], antibacterial [28][29][30][31][36][37], antiviral [27][28][29][30]…”