Synthesis and Biological Activities of Naturally Functionalized Polyamines: An Overview

Abstract

: Recently, extensive researches have emphasized the fact that polyamines conjugates are becoming important in all the biological and medicinal fields. In this review we will focus our attention on natural polyamines and highlight recent progress in both fundamental mechanism studies and interest for the development and application for a therapeutic human use of polyamine derivatives.

From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues

“…The diverse biological activity of aminosterols has been subjected to numerous reviews. Previous works covered the activity, mechanism of action, and prospects of squalamine and similar aminosterols as a new class of antibiotics capable of overcoming the problem of resistance [11,33,38,42,80,121], as well as their antifungal and antiviral properties [47,48]. Special attention was paid to their anti-angiogenic activity for the treatment of tumor diseases [122].…”

“…The goal of this review is to systematize the information available in the literature (up to 2021 with impact up to the most recent years) on the chemistry and biological activity of steroid polyamines, including their influence on the synthesis, properties, and perspectives of terpenoids with polyamine fragments. Despite the fact that many works have been devoted to the chemistry and pharmacology of steroid polyamines, including reviews [11,12,[31][32][33][34][35][36][37][38][39][40][41][42], until now the scientific literature has not summarized information on complete syntheses, various modifications and biological activity of steroid polyamines. The goal of this review is to systematize the information available in the literature (up to 2021 with impact up to the most recent years) on the chemistry and biological activity of steroid polyamines, including their influence on the synthesis, properties, and perspectives of terpenoids with polyamine fragments.…”

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

“…[16][17][18][19] Naturally occurring polyamine products have been isolated from various terrestrial and marine organisms, such as bacteria, fungi, protozoa, plants, sponges, corals, insects, sharks and sea lamprey. 3,[20][21][22][23][24] Polyamine-containing natural products (NPs) have a distinguishing aliphatic hydrocarbon backbone with two or more amino groups. Long chains or fused macrocyclic skeletons are also found in more complicated polyamine-containing NPs.…”

Green chemical and biological synthesis of cadaverine: recent development and challenges

“…It is a natural polyamine with various chemical and biological activity in humans, animals, plants, bacteria, fungi and other microbes. [1][2][3] Recently, cadaverine has been found to be used as an important monomer to develop a series of high value-added products with commercial prospects. It can participate in plant physiological processes such as cell division and growth, promoting the development of pistils and stamens, regulating the senescence process, improving fruit development, and increasing yield.…”

“…It is a natural polyamine with various chemical and biological activity in humans, animals, plants, bacteria, fungi and other microbes. 1–3 …”