Green chemical and biological synthesis of cadaverine: recent development and challenges

Huang, Yuhong; Ji, Xiuling; Zhan-ling, MA; Łężyk, Mateusz; Xue, Yaju; Zhao, Hai

doi:10.1039/d1ra02764f

Cited by 20 publications

(14 citation statements)

References 108 publications

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“…18), known as cadaverine. 85 Meanwhile, the deamination of lysine to 5-amino valeric acid ( M71 ) provides a monomer for Nylon 5 preparation. 86 Similarly, ornithin is biosynthesized from sugar and gives C4 diamines ( M72 ) via a similar decarboxylation step.…”

Section: Di-functional Monomers For Step-growth Polymerizationmentioning

confidence: 99%

Bio-based monomers for amide-containing sustainable polymers

Yan

Wang

et al. 2023

Chem. Commun.

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Section: Di-functional Monomers For Step-growth Polymerizationmentioning

confidence: 99%

Bio-based monomers for amide-containing sustainable polymers

Yan

Wang

et al. 2023

Chem. Commun.

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“…PLP showed as red fonts. (a) Cadaverine biosynthesis pathway in Escherichia coli (Huang et al, 2021). (b) 4‐dihydroxyphenylacetate‐ l ‐alanine ( l ‐DOPA) synthesis pathway (Wei et al, 2016).…”

Section: Biosynthesis Of Chemicals Which Plp Participated As Cofactormentioning

confidence: 99%

Advances and prospects in the biosynthesis of vitamin B₆ and its bioengineering as a cofactor of other chemicals

Liu

Jin

et al. 2022

Food Bioengineering

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Vitamin B6 is an essential nutrient, which is widely used in food products, feed additives, pharmaceuticals, disease diagnosis, and other fields. Pyridoxal‐5′‐phosphate (PLP), the active form of vitamin B6, is an important coenzyme participating in a variety of enzyme reactions. At present, the oxazole method is mainly used for the production of vitamin B6, but toxic and corrosive intermediates produced in the synthesis process, which does not conform to the green manufacturing. Therefore, there is considerable interest in shifting from chemical processes to sustainable fermentation techniques and research on PLP metabolism of other valuable compounds. In this review, we will briefly describe the enzymes that PLP participated and focus on the advances in vitamin B6 biosynthesis and discuss its application to engineering bacteria that overproduce other commercially valuable substances including cadaverine, 3,4‐dihydroxyphenylacetate‐l‐alanine, γ‐aminobutyric acid, and l‐phosphinothricin. It will provide a reference for the biosynthesis of vitamin B6 or other valuable compounds in which PLP participates in the reaction, and we also look forward to the future development prospect of PLP.

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“…Most of the currently studied lysine decarboxylases are sensitive to an alkaline environment . Normally, active decamers of lysine decarboxylase can be easily inactivated as dimers form under pH 8.0.…”

Section: Introductionmentioning

confidence: 99%

Ionozymes for Efficient Synthesis of Cadaverine: Offering a Sustainable Way for Bio-nylon 5X Production

Wang

Xue

et al. 2023

ACS Sustainable Chem. Eng.

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Bio-based cadaverine, a crucial monomer for the production of bio-nylon 5X, can be synthesized during the bioconversion of L-lysine HCl relying on lysine decarboxylases. The rationally designed lysine decarboxylase ΔLdcEt3 has exhibited outstanding alkaline stability in pH 8.0 (half-life: 362 h); however, its catalytic activity still needs to be improved to meet the requirements of industrial cadaverine production. A novel ionozyme strategy can create a preferable reaction microenvironment, affect the intermediate formation, and/or improve the enzymatic stability and activity. Therefore, ionozymes ΔLdcEt3-[Emim]Cl and ΔLdcEt3-[Ch][Ser] have been successfully developed for efficient cadaverine production in this study. The results showed that the catalytic activities of ΔLdcEt3-[Emim]Cl and ΔLdcEt3-[Ch][Ser] improved 124.2 and 116.2%, respectively. Meanwhile, the catalytic efficiencies (k cat /K m ) of ΔLdcEt3-[Emim]Cl and ΔLdcEt3-[Ch][Ser] were also increased by 1.5-and 1.2-fold, respectively. Particle size, circular dichroism, and Raman spectrum analyses showed that [Emim]Cl and [Ch][Ser] could affect short-range attractions related to the aggregation state and change the secondary structure. Protein surface analysis demonstrated that the addition of ionic liquids changed the hydrophobicity of ΔLdcEt3. In addition, isothermal titration calorimetry and molecular docking revealed that [Emim]Cl and [Ch][Ser] could promote the protein−ligand complexation during the enthalpy-driven L-lysine and ΔLdcEt3 binding process, which was confirmed by molecular dynamics. Therefore, ionozymes ΔLdcEt3-[Emim]Cl/[Ch][Ser] provide a novel possibility for high-level cadaverine production.

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Green chemical and biological synthesis of cadaverine: recent development and challenges

Abstract: Progress and strategies towards the green chemo/bio-synthesis of cadaverine with special attention to their environmental, economic, and applicable impact are reviewed.

Cited by 20 publications

References 108 publications

Bio-based monomers for amide-containing sustainable polymers

Bio-based monomers for amide-containing sustainable polymers

Advances and prospects in the biosynthesis of vitamin B₆ and its bioengineering as a cofactor of other chemicals

Ionozymes for Efficient Synthesis of Cadaverine: Offering a Sustainable Way for Bio-nylon 5X Production

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Green chemical and biological synthesis of cadaverine: recent development and challenges

Abstract: Progress and strategies towards the green chemo/bio-synthesis of cadaverine with special attention to their environmental, economic, and applicable impact are reviewed.

Cited by 20 publications

References 108 publications

Bio-based monomers for amide-containing sustainable polymers

Bio-based monomers for amide-containing sustainable polymers

Advances and prospects in the biosynthesis of vitamin B6 and its bioengineering as a cofactor of other chemicals

Ionozymes for Efficient Synthesis of Cadaverine: Offering a Sustainable Way for Bio-nylon 5X Production

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Product

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Advances and prospects in the biosynthesis of vitamin B₆ and its bioengineering as a cofactor of other chemicals