Synthesis and biological activities of Bis alkyl 1,3,4-oxadiazole incorporated azo dye derivatives

Synthesis and Antioxidant Activity of Bis (Aroyl/Arylsulfonyl Ethenesulfonylmethylazolyl)Pyridines

“…A new class of 2,6-pyridine linked bis (oxadiazoles), bis (thiadiazoles), and bis (triazoles) were synthesized by exploiting the synthetic intermediates pyridine-2,6dicarbohydrazide (1), E-aroylethenesulfonylacetic acid (2) and E-arylsulfonylethenesulfonyl-acetic acid (6). The cyclocondensation of 1 mol of compound 1 with 2 mol of 2 in the presence of phosphorus oxychloride under ultrasonication gave 2,6-(bis-2-aroylethene-sulfonylmethyl-1,3,4-oxadiazol-5-yl) pyridine (3). The thiadiazole and triazole rings were developed by the interconversion of oxadiazole with appropriate nucleophiles.…”

“…Among five membered heterocyclic compounds, azoles such as oxadiazoles, thiadiazoles, and triazoles are an indispensable class of heterocyclic family to display diverse pharmaceutical as well as biological applications . 1,3,4‐Oxadiazole and their derivatives presents antioxidant antimicrobial and anticonvulsant properties. Tiodazosin , nesapidil , and furamizole are some of the famous marketed drugs contain oxadiazole scaffold as major structural unit.…”

In vitro antioxidant activity of diazenyl schiff base molecules

“…Literature survey revealed that phenolic molecules or nitrogen bearing heterocyclic rings have good free radical scavenging activity (Shridhar et al, 2016;Chinnagiri et al, 2013). The molecules (5A and 5E) showed potential antioxidant activity and possess nitogen bearing heterocyclic ring.…”

Latest Update on Pharmacological Activities of 1,3,4-Oxadiazole Derivatives

“…The synthesized compounds were screened for their antimicrobial and in vitro antioxidant properties [30] (Figure 30). …”