Synthesis and Antioxidant Activity of Bis (Aroyl/Arylsulfonyl Ethenesulfonylmethylazolyl)Pyridines

Abstract

A new class of 2,6‐pyridine linked bis (oxadiazoles), bis (thiadiazoles), and bis (triazoles) were prepared from the synthetic intermediates pyridine‐2,6‐dicarbohydrazide, E‐aroylethenesulfonylacetic acid and E‐arylsulfonylethenesulfonylacetic acid adopting ultrasonication methodology and tested for their antioxidant activity. Among all the tested compounds 2,6‐(bis (2‐(4‐methylbenzoylethenesulfonylmethyl)‐1,3,4‐oxadiazol‐5‐yl))‐pyridine (7b) was found to be potential antioxidant agent.

Synthesis, Antimicrobial, and Antioxidant Screening of Aryl Acetic Acid Incorporated 1,2,4‐Triazolo‐1,3,4‐Thiadiazole Derivatives

“…The percentage of free radical scavenging was calculated by equation . IC 50 values of the test compounds were calculated from percentage scavenging activity (Table ) . where A is the absorbance of the control (containing methanolic DPPH and ascorbic acid) and B is the absorbance of the test compound (containing methanolic DPPH and test compound).…”

“…The percentage of free radical scavenging was calculated by equation 2. IC 50 values of the test compounds were calculated from percentage scavenging activity (Table 3) [18,19].…”

An investigation of the biological applications of sulphonated succinimides: in vivo toxicity to zebrafish larvae as well as antioxidant and antimicrobial potential

“…In recent years, many investigations have recorded the antioxidant properties of succinimide and sulphonyl moieties. A few examples are as follows: ruthenium complexes with succinimide ligands act against HL-60 leukemic cells and PBMCs, 26 the antioxidant potential of aldehydic-pyrrolidinedione against free radicals (ABTS, DPPH, and H 2 O 2 ), 1 the antioxidant property of ketoesters derivatives allow them to be used as supplements for the treatment of Alzheimer's disease, 12 sulfonyl ester-based heterocyclic Schiff bases against β-carotene linoleic acid and CUPRAC assays, 27 and bis(aroyl/arylsulfonyl ethene sulfonyl methyl azolyl)pyridine 28 and N -[(2-arylmethylthio)phenylsulfonyl] cinnamamide 29 against free radicals. Antibacterial studies of succinimide and sulphonyl moieties have also been reported.…”