Synthesis and Biological Activities of Novel Triazole Compounds Containing 1,3-Dioxolane Rings

Xu, Le; Zhang, Shusheng; Niu, Shuyan; Qin, Yong-Qi; Li, Xuemei; Jiao, Kui

doi:10.3390/91100913

Cited by 15 publications

(7 citation statements)

References 3 publications

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“…1,3-Dioxolane,4-ethyl-5-hexyl-2,2-bis(trifluoromethyl)-,cis-is a widely used medical intermediate and chemical intermediate of anti-cancer and anti-tumor [19]), and is widely used as the solvent and extractant of oil and fat, electrolyte of lithium ion battery, etc [20]. 1-Amino-2-(hydroxymethyl)anthraquinone can be multi-used as medical intermediate, raw material of healthy food, papermaking additives, material of disperse dye and vat dye [21].…”

Section: Resultsmentioning

confidence: 99%

Analysis of Biomedical Components of Camellia oleifera Leaf and Kernel Hull by GC/MS

Liu

Peng

Wu³

et al. 2009

2009 3rd International Conference on Bioinformatics and Biomedical Engineering

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Abundant leaves and kernel hulls of Tea-oil tree (Camellia oleifera) are still underutilized and wastefully abandoned to pollute environment. In order to solve this problem and better utilize the leaves and kernel hulls of C. oleifera, we used GC/MS technology to analyze the top value-added bioactive constituents of their benzene/ethanol extractives. After treated with freeze-drying, the fresh leaves and kernel hulls were extracted fully in benzene/ethanol, respectively, and then the two extractives were analyzed by online linked GC/MS. Relative content of each component was determined by area normalization. There are 25 components identified in the leaf extractive, and the main constituents are butyraldehyde,semicarbazone (11.58%), hexatriacontane (8.04%), 1,6-anhydro-.beta.-D-glucopyranose, (7.54%), octadecane (7.53%), benzeneacetic acid,4-hydroxy-(6.59%), 1,3-dioxolane,4-ethyl-5-hexyl-2,2-bis(trifluoro methyl)-,cis-(6.53%), etc. The extractive of kernel hull also contains abundant constituents identified as: 2-furancarboxaldehyde,5-(hydroxymethyl)-(32.37%), 1,3-propanediol,2-ethyl-2-(hydroxymethyl)-(28.34%), 1,2,3-benzenetriol (15.10%), etc. As the first report here, the analytical result by GC/MS showed that the benzene/ethanol extractives of both leaf and kernel hull of C. oleifera contain abundant components of rare natural medicinal materials, and also contain many components which can be developed into two value-added materials of high-grade cosmetic, bioenergy, and industrial solvent.

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Section: Resultsmentioning

confidence: 99%

Analysis of Biomedical Components of Camellia oleifera Leaf and Kernel Hull by GC/MS

Liu

Peng

Wu³

et al. 2009

2009 3rd International Conference on Bioinformatics and Biomedical Engineering

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“…IIa-g and Va-k ( Fig. 1 and Table 1) Antifungal activities of IIa-g and Va-k were evaluated by a procedure described in our previous paper [9]. A mixture of the same amount of water, N,N-dimethylformamide, and Tween 20 was used as a negative control.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and QSAR studies on 1-[(5-substituted-1,3,4-thiadiazol-2-yl)methyl]-1H-1,2,4-triazole as antifungal agents

et al. 2009

Struct Chem

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A series of 1-[(1,3,4-thiadiazol-2-yl)methyl]-1H-1,2,4-triazole derivatives were prepared and evaluated for their antifungal activities. The chemical structures of these compounds were determined by means of elemental analyses, 1 H NMR, and X-ray crystallography. Quantitative structureactivity relationship (QSAR) studies were performed on these compounds using physicochemical parameters as independent parameters and antifungal activity as a dependent parameter, where antifungal activity correlated best (r [ 0.9) with hydrophobic parameters (p) and indicator (H). Moreover, the results are interpreted on the basis of a multiple regression model. The model has been internally and externally validated. Furthermore, the domain of applicability which indicates the area of reliable predictions is defined.

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“…Various heterocycles containing triazole ring . have been synthesized [2][3][4][5][6][7][8][9][10]. They show a variety of interesting biological activities and can be used as antimicrobial agents [2][3][4][5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 2-(5-(4-fluorophenyl)-3-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)-4-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)thiazole, C₂₉H₂₅FN₆S

Ghabbour

Abdel‐Wahab

Alamri

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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Synthesis and Biological Activities of Novel Triazole Compounds Containing 1,3-Dioxolane Rings

Cited by 15 publications

References 3 publications

Analysis of Biomedical Components of Camellia oleifera Leaf and Kernel Hull by GC/MS

Analysis of Biomedical Components of Camellia oleifera Leaf and Kernel Hull by GC/MS

Synthesis and QSAR studies on 1-[(5-substituted-1,3,4-thiadiazol-2-yl)methyl]-1H-1,2,4-triazole as antifungal agents

Crystal structure of 2-(5-(4-fluorophenyl)-3-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)-4-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)thiazole, C₂₉H₂₅FN₆S

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Synthesis and Biological Activities of Novel Triazole Compounds Containing 1,3-Dioxolane Rings

Cited by 15 publications

References 3 publications

Analysis of Biomedical Components of Camellia oleifera Leaf and Kernel Hull by GC/MS

Analysis of Biomedical Components of Camellia oleifera Leaf and Kernel Hull by GC/MS

Synthesis and QSAR studies on 1-[(5-substituted-1,3,4-thiadiazol-2-yl)methyl]-1H-1,2,4-triazole as antifungal agents

Crystal structure of 2-(5-(4-fluorophenyl)-3-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)-4-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)thiazole, C29H25FN6S

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Crystal structure of 2-(5-(4-fluorophenyl)-3-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)-4-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)thiazole, C₂₉H₂₅FN₆S