Crystal structure of 2-(5-(4-fluorophenyl)-3-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)-4-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)thiazole, C₂₉H₂₅FN₆S

Synthesis and Characterization of Novel 2-(1,2,3-Triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles and 2-(4,5-Dihydro-1H-pyrazol-1-yl)-4-(1H-1,2,3-triazol-4-yl)thiazoles

“…Triazolylthiazoles can be produced from the cyclization of Schiff bases containing a triazole moiety in the presence of mercaptoacetic acids, or from carbohydrazides containing thiazole units and isothiocyanates or carbon disulfides, followed by cyclization and elimination of hydrogen sulfide [28]. Recently, we have reported the synthesis and crystal structures of novel heterocycles containing thiazole, pyrazoline, and 1,2,4-triazole moieties [29][30][31] as part of our long-term interest in new biologically active heterocycles [32][33][34]. In the current work, we report the synthesis of 2-(1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles and 2-(4,5-dihydro-1H-pyrazol-1-yl)-4-(1H-1,2,3-triazol-4-yl)thiazoles using simple procedures and their structure characterization.…”

The crystal structure of 2-(3-(4-bromophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-8H-indeno[1,2-d]thiazole, C25H17BrFN3S

“…The most common synthetic methods for pyrazoles involve a treatment of 1,3-difunctional compounds with hydrazines [10], whereas thiazoles are commonly synthesized through Hantzsch, Gabriel, and Cook-Heilborn's syntheses [11]. Recently, the X-ray crystal structures of related compounds have been reported [12][13][14][15]. The asymmetric unit of the title structure consists of two independent molecules (see the figure).…”

Synthesis and Structural Characterization of Isostructural 4-(4-Aryl)-2-(5-(4-fluorophenyl)-3-(1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles

“…Furthermore, the Hantzsch condensation of thiourea and 2bromoacetophenones provided 2-aminothiazoles [32]. Recently, we have synthesized a number of heterocycles containing pyrazole, thiazole and 1,2,3-triazole moieties [33,34] and some crystal structures have been established [35,36].…”