Synthesis and Biological Activities of Heterocyclic Hybrids Containing Piperidine and Pyridine Moieties: Recent Developments

Abstract

Piperidine and pyridine nuclei are essential heterocyclic systems and act as an essential underpinning for agriculture, medicines, industries, etc. The development of novel methods for the synthesis of these exemplary heterocyclic compounds and their respective hybrids, which show a wide range of biological activities, is a very fascinating theme. The derivatives of these pervasive nuclei are used as antibacterial, antimicrobial, antifungal, antimalarial, anticancer, antiproliferative, antihypertensive, antiparasitic, and many other agents. The hybrids of these nuclei have retained a distinct position in medicinal chemistry and are often incorporated in synthetic drug discovery. In this review, we have compiled relevant literature on different derivatives of piperidine and pyridine moieties and their biological activities.

Synthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (Mpro)

“…The design and synthesis of novel compounds, particularly those incorporating imidazole scaffolds with azo functionality, present promising avenues for developing M pro inhibitors with diverse biological activities 36 – 41 . Moreover, employing ultrasonic-assisted synthesis aligns with sustainable practices in medicinal chemistry.…”