Synthesis and Bioactivity Screening of New 1, 3-Thiazolidin-4-One Compounds Bearing (Thiadiazols / Triazoles) Moieties

Abstract

This article deals with synthesis, Identification and biological activity screening of variety 1,3-thiazolidin-4-ones entitled 3,3’-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis[(5-methyl-2-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one)] 6a-d and 3,3’-[benzene-1,3-diylbis(5-mercapto-4H-1,2,4-triazole-3,4-diyl)]bis[5-methyl-2-(5-substitutedpyridine-2-yl)-1,3-thiazolidin-4-one], 7a-d. On cyclocondensation reaction of newly Schiff bases and thiolactic acid, some new derivatives of 1,3-thiazolidin-4-ones have been obtained in presence of anhydrous zinc chloride. The elemental analysis, proton NMR spectra of were outlined for structures confirmation. An agreement for the proposed structures of synthesized compounds were approved based on the elemental analysis, IR and 1H NMR spectra. Antimicrobial activity of the newly thiazolidinones have been evaluated with powerful results.

Synthesis and Characterization of 4-Thiazolidinones Derivatives with 6-Chlorobenzothiazole Moiety

“…In this case, the reaction begins with a nucleophilic attack of the sulfur atom on the carbon atom of the imino group, followed by intramolecular cyclization, which results in the elimination of water molecule. As a result, high yields were obtained when anhydrous ZnCl2 was utilized as a dehydrating agent as well as to speed up the final stage of the cyclization reaction [20]. Overall, the reactions went successfully, with modest yields and no unwanted byproducts formed.…”

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

“…The screening of symmentrical bis-thiazolidin-4-ones (130a-130d and 131a-131d) for their antimicrobial activity showed good antifungal activity and moderate antibacterial effects in some cases. Therefore, Compounds 130c and 131d showed comparable zone of inhibition to ketoconazole (19 mm vs. 18mm) against A. flavus, while 130a, 131a and 131d demonstrated comparable activity to ketoconazole against C. albicans (19-22 mm vs. 24 mm) [135].…”