Synthesis and Characterization of 4-Thiazolidinones Derivatives with 6-Chlorobenzothiazole Moiety

Abstract

The 4-thiazolidinone ring system is a fundamental structure which is present in a large variety of synthetic pharmaceuticals that has a wide range of potential biological effects. In this work, thioglycolic acid and 6-chloro-N-(substituted benzylidene)benzothiazol-2-amine were condensed in DMF solvent in the presence of ZnCl2 to obtain novel 3- (6-chlorobenzo[d]thiazol-2-yl)-2-(substituted aryl)thiazolidin-4-one derivatives. The structure of the synthesized compounds (3a-j) were confirmed using IR, 1H & 13C NMR and mass spectroscopy.